ArticleBMC pulmonary medicine2014
Validation of a portable nitric oxide analyzer for screening in primary ciliary dyskinesias.
Article in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols.Annals of the American Thoracic Society · 2020Guideline
- Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2018Pooled it
- Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia. A Systematic Review and Meta-analysis.Annals of the American Thoracic Society · 2017Pooled it
- European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia.The European respiratory journal · 2017Guideline
- Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review.Pediatric pulmonology · 2016Guideline
- Diagnostic accuracy of nasal nitric oxide for establishing diagnosis of primary ciliary dyskinesia: a meta-analysis.BMC pulmonary medicine · 2015Pooled it
- The Value of Nasal Nitric Oxide Measurement in the Diagnosis of Primary Ciliary Dyskinesia.Pediatric pulmonology · 2026Review
- Electrochemical nasal nitric oxide measurement during laryngeal mask ventilation as primary ciliary dyskinesia screening.ERJ open research · 2025Article
- Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine.Children (Basel, Switzerland) · 2023Review
- Nasal nitric oxide measurement variability to establish a standard for reliable results.ERJ open research · 2022Article
- An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia.ERJ open research · 2022Article
- Feasibility of nasal NO screening in healthy newborns.Pediatric pulmonology · 2022Article
- Progress in Diagnosing Primary Ciliary Dyskinesia: The North American Perspective.Diagnostics (Basel, Switzerland) · 2021Review
- Motile ciliopathies.Nature reviews. Disease primers · 2020Review
- Primary ciliary dyskinesia: a major player in a bigger game.Breathe (Sheffield, England) · 2020Review
- Registries and collaborative studies for primary ciliary dyskinesia in Europe.ERJ open research · 2020Review
- Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma.Journal of clinical medicine · 2019Review
- Severe pulmonary disease in an adult primary ciliary dyskinesia population in Brazil.Scientific reports · 2019Article
- Cost-effectiveness analysis of three algorithms for diagnosing primary ciliary dyskinesia: a simulation study.Orphanet journal of rare diseases · 2019Article
- Diagnosis of primary ciliary dyskinesia: potential options for resource-limited countries.European respiratory review : an official journal of the European Respiratory Society · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNasal nitric oxide (nNO) levels are very low in primary ciliary dyskinesia (PCD) and it is used as a screening test.
methodsWe assessed the reliability and usability of a hand-held analyser in comparison to a stationary nitric oxide (NO) analyser in 50 participants (15 healthy, 13 PCD, 22 other respiratory diseases; age 6-79 years). Nasal NO was measured using a stationary NO analyser during a breath-holding maneuver, and using a hand-held analyser during tidal breathing, sampling at 2 ml/sec or 5 ml/sec. The three methods were compared for their specificity and sensitivity as a screen for PCD, their success rate in different age groups, within subject repeatability and acceptability. Correlation between methods was assessed.
resultsValid nNO measurements were obtained in 94% of participants using the stationary analyser, 96% using the hand-held analyser at 5 ml/sec and 76% at 2 ml/sec. The hand-held device at 5 ml/sec had excellent sensitivity and specificity as a screening test for PCD during tidal breathing (cut-off of 30 nL/min,100% sensitivity, >95% specificity). The cut-off using the stationary analyser during breath-hold was 38 nL/min (100% sensitivity, 95% specificity). The stationary and hand-held analyser (5 ml/sec) showed reasonable within-subject repeatability(% coefficient of variation = 15).
conclusionThe hand-held NO analyser provides a promising screening tool for PCD.
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Registered trials
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