Evidence map›Paper›PMID 24507620›Full record

ArticleJournal of neuroimmunology2014

Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

Hayk Davtyan, Anahit Ghochikyan, Armine Hovakimyan, Irina Petrushina, Jianmei Yu, David Flyer, Peter Juul Madsen, Lars Ostergaard Pedersen, David H Cribbs, Michael G Agadjanyan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Vaccines for Alzheimer's disease: a brief scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  2. Article
  3. Article
  4. Alzheimer's disease: is a vaccine possible?Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hayk DavtyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
Anahit GhochikyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
Armine HovakimyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
Irina PetrushinaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
Jianmei YuIntercell USA, Inc., Gaithersburg, MD 20878, USA.
David FlyerIntercell USA, Inc., Gaithersburg, MD 20878, USA.
Peter Juul MadsenH. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.
Lars Ostergaard PedersenH. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, CA 92697, USA.
Michael G AgadjanyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA. Electronic address: magadjanyan@immed.org.

Funding

Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Combining AD Epitope Vaccine with Innate ImmunityR01NS050895 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2004 to 2018
$7.4M
Multiple Approaches to Abeta Vaccination in Animal ModelsR01AG020241 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2001 to 2016
$5.6M
Multiple Approaches to Abeta Vaccination in Animal ModelsRF1AG020241 · NIA · INSTITUTE FOR MOLECULAR MEDICINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2018 to 2018
$3.3M
Immunogenicity & efficacy of chimeric flu virus expressing Ab42 B cell epitopeR01NS057395 · NINDS · INSTITUTE FOR MOLECULAR MEDICINE · PI AGADJANYAN, MICHAEL G · 2008 to 2012
$2.0M
NIA NIH HHS AG00096NIA NIH HHS AG-20241NIA NIH HHS R01 AG020241NIA NIH HHS RF1 AG020241NIA NIH HHS T32 AG000096NINDS NIH HHS NS-057395NINDS NIH HHS NS-50895NINDS NIH HHS R01 NS050895NINDS NIH HHS R01 NS057395
6 · The paper itself

Abstract

Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as an adjuvant in the clinical arena.

Indexed as

Adjuvants, ImmunologicAlzheimer VaccinesAmyloid beta-PeptidesAnimalsAntibodies, ViralBacterial ToxinsDisease Models, AnimalEnterotoxinsEnzyme-Linked Immunosorbent AssayEpitopes, B-LymphocyteEpitopes, T-LymphocyteEscherichia coliEscherichia coli ProteinsFemaleLymphocyte ActivationMiceAdjuvants, ImmunologicAlzheimer VaccinesAmyloid beta-PeptidesAntibodies, ViralBacterial ToxinsEnterotoxinsEpitopes, B-LymphocyteEpitopes, T-LymphocyteEscherichia coli Proteinsheat-labile enterotoxin, E coliVaccines, DNAAlzheimer's diseaseEpitope vaccineImmune responsesImmunostimulatory patch

Identifiers

PMID24507620
PMCPMC3951952

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.