Evidence map›Paper›PMID 24507618›Full record

ArticleBiophysical journal2014

On the GFP-based analysis of dynamic concentration profiles.

Alexander M Berezhkovskii, Stanislav Y Shvartsman

Open access · bronzeAbstract readLetter
In one paragraph

Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alexander M BerezhkovskiiMathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland.
Stanislav Y ShvartsmanDepartment of Chemical and Biological Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey. Electronic address: stas@princeton.edu.
National Institutes of Health · USPrinceton University · US

Funding

Systems biology of MAPK signaling in early drosophila embryoR01GM086537 · NIGMS · PRINCETON UNIVERSITY · PI BURDINE, REBECCA D., GOLDSMITH, ELIZABETH J. · 2011 to 2018
$3.1M
Modeling of kinetic processes in biological systemsZIACT000273 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI BEREZHKOVSKII, ALEXANDER · 2009 to 2021
$2.1M
FDA HHS R01BM086537NIGMS NIH HHS R01 GM086537
6 · The paper itself

Abstract

Studies with GFP-tagged proteins can be used to investigate the dynamics of concentration profiles of regulatory proteins in cells and tissues. Analysis of these experiments must account for the finite rate with which the GFP-tagged proteins mature to the fluorescent state. Toward this end, we present an analytical framework that provides an explicit connection between the apparent kinetics of concentration gradients and the rates of GFP maturation.

Indexed as

AnimalsDrosophilaFluorescenceGreen Fluorescent ProteinsModels, BiologicalMorphogenesisGreen Fluorescent Proteins

Identifiers

PMID24507618
PMCPMC3945030
OpenAlexW2018014471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.