ArticleBiophysical journal2014
Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models.Islets · 2023Review
- Article
- Mathematical modeling clarifies the paracrine roles of insulin and glucagon on the glucose-stimulated hormonal secretion of pancreatic alpha- and beta-cells.Frontiers in endocrinology · 2023Article
- Article
- Modelling System of Two Insulin-Glucose Delays to Achieve the Dynamics of Glucose Changes.Journal of biomedical physics & engineering · 2022Article
- A glucose-insulin-glucagon coupled model of the isoglycemic intravenous glucose infusion experiment.Frontiers in physiology · 2022Article
- Intercellular Communication in the Islet of Langerhans in Health and Disease.Comprehensive Physiology · 2021Article
- Article
- A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease.Frontiers in computational neuroscience · 2021Article
- Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia.Frontiers in endocrinology · 2021Review
- Mathematical Model of Glucagon Kinetics for the Assessment of Insulin-Mediated Glucagon Inhibition During an Oral Glucose Tolerance Test.Frontiers in endocrinology · 2021Article
- Article
- Calcium Oscillations in Pancreatic α-cells Rely on Noise and ATP-Driven Changes in Membrane Electrical Activity.Frontiers in physiology · 2020Article
- Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells.Royal Society open science · 2020Article
- δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.The Journal of physiology · 2018Article
- CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Scientific reports · 2017Article
- Functional identification of islet cell types by electrophysiological fingerprinting.Journal of the Royal Society, Interface · 2017Article
- Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells.Scientific reports · 2016Article
- Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.Upsala journal of medical sciences · 2016Review
- Glucagon secretion from pancreatic α-cells.Upsala journal of medical sciences · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which glucose induces insulin secretion in β-cells is fairly well understood. Despite years of research, however, the mechanism of glucagon secretion in α-cells is still not well established. It has been proposed that glucose regulates glucagon secretion by decreasing the conductance of either outward ATP-dependent potassium channels (K(ATP)) or an inward store-operated current (SOC). We have developed a mathematical model based on mouse data to test these hypotheses and found that both mechanisms are possible. Glucose metabolism closes K(ATP) channels, which depolarizes the cell but paradoxically reduces calcium influx by inactivating voltage-dependent calcium and sodium channels and decreases secretion. Glucose metabolism also activates SERCA pumps, which fills the endoplasmic reticulum and hyperpolarizes the cells by reducing the inward current through SOC channels and again suppresses glucagon secretion. We find further that the two mechanisms can combine to account for the nonmonotonic dependence of secretion on glucose observed in some studies, an effect that cannot be obtained with either mechanism alone.
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Registered trials
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