ArticleBiophysical journal2014
Determinants of fluidlike behavior and effective viscosity in cross-linked actin networks.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Rheological and Bioactive Profile of Gelatin-Hemp Protein Hydrogels.Molecules (Basel, Switzerland) · 2026Article
- Crosslinker identity and dynamics regulate F-actin network structure and mechanics.Frontiers in cell and developmental biology · 2026Article
- Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis.APL bioengineering · 2025Review
- Competing instabilities reveal how to rationally design and control active crosslinked gels.Nature communications · 2022Article
- A tug of war between filament treadmilling and myosin induced contractility generates actin rings.eLife · 2022Article
- Mechanics of stabilized intercellular bridges.Biophysical journal · 2022Article
- Simulations of dynamically cross-linked actin networks: Morphology, rheology, and hydrodynamic interactions.PLoS computational biology · 2021Article
- Protein friction and filament bending facilitate contraction of disordered actomyosin networks.Biophysical journal · 2021Article
- Cell mechanical properties of human breast carcinoma cells depend on temperature.Scientific reports · 2021Article
- Nonlinear Elastic and Inelastic Properties of Cells.Journal of biomechanical engineering · 2020Review
- Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes.Science advances · 2020Article
- RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis.Developmental cell · 2020Article
- Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes.Nature communications · 2020Article
- The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model.PLoS computational biology · 2020Article
- Varying crosslinking motifs drive the mesoscale mechanics of actin-microtubule composites.Scientific reports · 2019Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Scaling behaviour in steady-state contracting actomyosin networks.Nature physics · 2019Article
- Cholesterol Depletion by MβCD Enhances Cell Membrane Tension and Its Variations-Reducing Integrity.Biophysical journal · 2019Article
- Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex.PLoS computational biology · 2017Article
- Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.Nature communications · 2017Article
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3 authors.
Funding
Abstract
The actin cortex has a well-documented ability to rapidly remodel and flow while maintaining long-range connectivity, but how this is achieved remains poorly understood. Here, we use computer simulations to explore how stress relaxation in cross-linked actin networks subjected to extensional stress depends on the interplay between network architecture and turnover. We characterize a regime in which a network response is nonaffine and stress relaxation is governed by the continuous dissipation of elastic energy via cyclic formation, elongation, and turnover of tension-bearing elements. Within this regime, for a wide range of network parameters, we observe a constant deformation (creep) rate that is linearly proportional to the rate of filament turnover, leading to a constant effective viscosity that is inversely proportional to turnover rate. Significantly, we observe a biphasic dependence of the creep rate on applied stress: below a critical stress threshold, the creep rate increases linearly with applied stress; above that threshold, the creep rate becomes independent of applied stress. We show that this biphasic stress dependence can be understood in terms of the nonlinear force-extension behavior of individual force-transmitting network elements. These results have important implications for understanding the origins and control of viscous flows both in the cortex of living cells and in other polymer networks.
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