ArticleNeuron2014
A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 125 citations in OpenAlex.
- Cold sensing by a glutamate receptor drives avoidance behavior in Drosophila larvae.Current biology : CB · 2026Article
- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
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- A new system for studying neuronal remodeling and its relation to behavior in Drosophila.Communications biology · 2025Article
- Multilayer control of KaiR1D-autoreceptor function by the auxiliary protein Neto.bioRxiv : the preprint server for biology · 2025Article
- Oviposition Response to Light With Different Spectra in the Crepuscular MothEcology and evolution · 2025Article
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- Drosophila require both green and UV wavelengths for sun orientation but lack a time-compensated sun compass.The Journal of experimental biology · 2024Article
- Neuronal wiring diagram of an adult brain.Nature · 2024Article
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- Hue selectivity from recurrent circuitry in Drosophila.Nature neuroscience · 2024Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- Neuronal "parts list" and wiring diagram for a visual system.bioRxiv : the preprint server for biology · 2024Article
- Horizontal-cell like Dm9 neurons inFrontiers in molecular neuroscience · 2024Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- SynLight: a bicistronic strategy for simultaneous active zone and cell labeling in the Drosophila nervous system.G3 (Bethesda, Md.) · 2023Article
- Article
- SynLight: a dicistronic strategy for simultaneous active zone and cell labeling in thebioRxiv : the preprint server for biology · 2023Article
- Neuronal wiring diagram of an adult brain.bioRxiv : the preprint server for biology · 2023Article
- Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Many visual animals have innate preferences for particular wavelengths of light, which can be modified by learning. Drosophila's preference for UV over visible light requires UV-sensing R7 photoreceptors and specific wide-field amacrine neurons called Dm8. Here we identify three types of medulla projection neurons downstream of R7 and Dm8 and show that selectively inactivating one of them (Tm5c) abolishes UV preference. Using a modified GRASP method to probe synaptic connections at the single-cell level, we reveal that each Dm8 neuron forms multiple synaptic contacts with Tm5c in the center of Dm8's dendritic field but sparse connections in the periphery. By single-cell transcript profiling and RNAi-mediated knockdown, we determine that Tm5c uses the kainate receptor Clumsy to receive excitatory glutamate input from Dm8. We conclude that R7s→Dm8→Tm5c form a hard-wired glutamatergic circuit that mediates UV preference by pooling ∼16 R7 signals for transfer to the lobula, a higher visual center. VIDEO ABSTRACT:
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.