Evidence map›Paper›PMID 24507186›Full record

ReviewNeuron2014

SIRT1 in neurodevelopment and brain senescence.

A Zara Herskovits, Leonard Guarente

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 4 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 4 syntheses or guidelines pooled it, 13 citations in OpenAlex.

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219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

A Zara HerskovitsDepartment of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Biology and Glenn Laboratories for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68-280, Cambridge, MA 02139, USA. Electronic address: aherskov@mit.edu.
Leonard GuarenteDepartment of Biology and Glenn Laboratories for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68-280, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: leng@mit.edu.
Brigham and Women's Hospital · USMassachusetts Institute of Technology · US

Funding

MOLECULAR STUDY OF YEAST SGS1 AND RDNA CIRCLES IN AGINGR01AG015339 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 1999 to 2014
$5.5M
Function of SIRT1 in Growth and ReproductionR01AG011119 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 1993 to 2016
$2.8M
NIA NIH HHS R01 AG011119NIA NIH HHS R01 AG015339
6 · The paper itself

Abstract

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals. These proteins also play an important role in maintaining neuronal health during aging. During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth, and dendritic branching. This sirtuin also plays a role in memory formation by modulating synaptic plasticity. Hypothalamic functions that affect feeding behavior, endocrine function, and circadian rhythmicity are all regulated by SIRT1. Finally, SIRT1 plays protective roles in several neurodegenerative diseases including Alzheimer's, Parkinson's, and motor neuron diseases, which may relate to its functions in metabolism, stress resistance, and genomic stability. Drugs that activate SIRT1 may offer a promising approach to treat these disorders.

Indexed as

AgingAnimalsBrainHumansLearningModels, BiologicalNeurodegenerative DiseasesNeuronsSirtuin 1SIRT1 protein, humanSirtuin 1

Identifiers

PMID24507186
PMCPMC4040287
OpenAlexW1544057566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.