Evidence map›Paper›PMID 24507156›Full record

ReviewAdvances in immunology2014

Recognition of tumors by the innate immune system and natural killer cells.

Assaf Marcus, Benjamin G Gowen, Thornton W Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin, David H Raulet

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 2 pooled it
46.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 2 syntheses or guidelines pooled it, 362 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Umbilical cord blood-derived natural killer cells:Annals of medicine and surgery (2012) · 2026
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  7. Review
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  15. Inflammation in Penile Squamous Cell Carcinoma: A Comprehensive Review.International journal of molecular sciences · 2025
    Review
  16. Article
  17. Article
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  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Assaf MarcusDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Benjamin G GowenDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Thornton W ThompsonDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Alexandre IannelloDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Michele ArdolinoDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Weiwen DengDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Lin WangDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
Nataliya ShifrinDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA.
David H RauletDepartment of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, USA. Electronic address: raulet@berkeley.edu.
University of California, Berkeley · US

Funding

EXPRESSION OF CLASS I-SPECIFIC RECEPTORS IN NK CELLSR01AI039642 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 1996 to 2014
$4.9M
Role of NKG2D in immune responses to turmorsR01CA093678 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2003 to 2019
$4.2M
NCI NIH HHS R01 CA093678NCI NIH HHS R01-CA093678NIAID NIH HHS R01 AI039642NIAID NIH HHS R01-AI039642
6 · The paper itself

Abstract

In recent years, roles of the immune system in immune surveillance of cancer have been explored using a variety of approaches. The roles of the adaptive immune system have been a major emphasis, but increasing evidence supports a role for innate immune effector cells such as natural killer (NK) cells in tumor surveillance. Here, we discuss some of the evidence for roles in tumor surveillance of innate immune cells. In particular, we focus on NK cells and other immune cells that express germline-encoded receptors, often labeled NK receptors. The impact of these receptors and the cells that express them on tumor suppression is summarized. We discuss in detail some of the pathways and events in tumor cells that induce or upregulate cell-surface expression of the ligands for these receptors, and the logic of how those pathways serve to identify malignant, or potentially malignant cells. How tumors often evade tumor suppression mediated by innate killer cells is another major subject of the review. We end with a discussion on some of the implications of the various findings with respect to possible therapeutic approaches.

Indexed as

AnimalsBinding SitesHumansImmunity, InnateKiller Cells, NaturalLigandsLymphocytes, Tumor-InfiltratingNeoplasmsLigandsCancerDNA-damage responseDNAM-1ImmunoeditingInnate immunityNKG2DProliferationSenescenceTumor immunosurveillance

Identifiers

PMID24507156
PMCPMC4228931
OpenAlexW127707871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.