ArticleThe Journal of allergy and clinical immunology2014
Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?
Article in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Pooled it
- Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology.The journal of allergy and clinical immunology. In practice · 2025Review
- Real-life effectiveness of indacaterol/glycopyrronium/mometasone for symptomatic relief of cough after switching from inhaled corticosteroid/long-acting βERJ open research · 2023Article
- Review
- Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium.BMC pulmonary medicine · 2022Article
- TRP channels in airway sensory nerves.Neuroscience letters · 2021Review
- Management of chronic refractory cough in adults.European journal of internal medicine · 2020Review
- Cough as an adverse effect on inhalation pharmaceutical products.British journal of pharmacology · 2020Review
- Increased expression of TRPV1 in patients with acute or chronic cough after lung cancer surgery.Thoracic cancer · 2019Article
- Coughing in Small Animal Patients.Frontiers in veterinary science · 2019Review
- Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma.BMC pulmonary medicine · 2018Article
- Managing patients with chronic cough: challenges and solutions.Therapeutics and clinical risk management · 2018Article
- The evidence on tiotropium bromide in asthma: from the rationale to the bedside.Multidisciplinary respiratory medicine · 2017Review
- Tiotropium in asthma: back to the future of anticholinergic treatment.Clinical and molecular allergy : CMA · 2017Review
- Capsaicin for Rhinitis.Current allergy and asthma reports · 2016Review
- Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.American journal of respiratory and critical care medicine · 2016Article
- Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.The Journal of pharmacology and experimental therapeutics · 2016Article
- Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials.BMJ open respiratory research · 2016Article
- Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory Syncytial Virus Infection.Journal of virology · 2015Article
- Neural Abnormalities in Nonallergic Rhinitis.Current allergy and asthma reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent studies have suggested that the long-acting muscarinic receptor antagonist tiotropium, a drug widely prescribed for its bronchodilator activity in patients with chronic obstructive pulmonary disease and asthma, improves symptoms and attenuates cough in preclinical and clinical tussive agent challenge studies. The mechanism by which tiotropium modifies tussive responses is not clear, but an inhibition of vagal tone and a consequent reduction in mucus production from submucosal glands and bronchodilation have been proposed.
objectiveThe aim of this study was to investigate whether tiotropium can directly modulate airway sensory nerve activity and thereby the cough reflex.
methodsWe used a conscious cough model in guinea pigs, isolated vagal sensory nerve and isolated airway neuron tissue- and cell-based assays, and in vivo single-fiber recording electrophysiologic techniques.
resultsInhaled tiotropium blocked cough and single C-fiber firing in the guinea pig to the transient receptor potential (TRP) V1 agonist capsaicin, a clinically relevant tussive stimulant. Tiotropium and ipratropium, a structurally similar muscarinic antagonist, inhibited capsaicin responses in isolated guinea pig vagal tissue, but glycopyrrolate and atropine did not. Tiotropium failed to modulate other TRP channel-mediated responses. Complementary data were generated in airway-specific primary ganglion neurons, demonstrating that tiotropium inhibited capsaicin-induced, but not TRPA1-induced, calcium movement and voltage changes.
conclusionFor the first time, we have shown that tiotropium inhibits neuronal TRPV1-mediated effects through a mechanism unrelated to its anticholinergic activity. We speculate that some of the clinical benefit associated with taking tiotropium (eg, in symptom control) could be explained through this proposed mechanism of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.