ReviewCellular microbiology2014
Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections.
Review in Cellular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Review
- Using CryopreservedMicroorganisms · 2023Article
- Current status of experimental models for the study of malaria.Parasitology · 2022Review
- Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice.Frontiers in immunology · 2021Article
- Modeling Infectious Diseases in Mice with a "Humanized" Immune System.Microbiology spectrum · 2019Review
- Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.Disease models & mechanisms · 2018Article
- Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.Malaria journal · 2018Review
- Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity.Frontiers in immunology · 2018Review
- Humanized Mice Are Instrumental to the Study ofFrontiers in immunology · 2018Review
- Characterization ofFrontiers in microbiology · 2018Article
- Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice.Frontiers in immunology · 2018Article
- Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.The FEBS journal · 2017Review
- Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.Scientific reports · 2017Article
- Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.Frontiers in cellular and infection microbiology · 2017Review
- Malaria modeling: In vitro stem cells vs in vivo models.World journal of stem cells · 2016Review
- Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.Pharmaceutical research · 2016Article
- Application of Humanized Mice in Immunological Research.Methods in molecular biology (Clifton, N.J.) · 2016Review
- Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.Nature protocols · 2015Article
- Influence of age, irradiation and humanization on NSG mouse phenotypes.Biology open · 2015Article
- Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax.Pathogens and global health · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Forty percent of people worldwide are at risk of malaria infection, and despite control efforts it remains the most deadly parasitic disease. Unfortunately, rapid discovery and development of new interventions for malaria are hindered by the lack of small animal models that support the complex life cycles of the main parasite species infecting humans. Such tools must accommodate human parasite tropism for human tissue. Mouse models with human tissue developed to date have already enhanced our knowledge of human parasites, and are useful tools for assessing anti-parasitic interventions. Although these systems are imperfect, their continued refinement will likely broaden their utility. Some of the malaria parasite's interactions with human hepatocytes and human erythrocytes can already be modelled with available humanized mouse systems. However, interactions with other relevant human tissues such as the skin and immune system, as well as most transitions between life cycle stages in vivo will require refinement of existing humanized mouse models. Here, we review the recent successes achieved in modelling human malaria parasite biology in humanized mice, and discuss how these models have potential to become a valuable part of the toolbox used for understanding the biology of, and development of interventions to, malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.