ArticleMedical physics2014
Comparison of flat cleaved and cylindrical diffusing fibers as treatment sources for interstitial photodynamic therapy.
Article in Medical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Optical-thermal modeling and treatment planning of ICG-enhanced interstitial photothermal therapy using cylindrical diffuser fibers.Lasers in medical science · 2026Article
- Robustness of interstitial photodynamic therapy treatment planning under power and positional uncertainties in light delivery.Scientific reports · 2026Article
- Photodynamic Effectiveness of Copper-Iminopyridine Photosensitizers Coupled to Zinc Oxide Nanoparticles AgainstInternational journal of molecular sciences · 2025Article
- CRISPR editing to mimic porphyria combined with light: A new preclinical approach for prostate cancer.Molecular therapy. Oncology · 2024Article
- Integrating clinical access limitations into iPDT treatment planning with PDT-SPACE.Biomedical optics express · 2023Article
- Review
- Interstitial Photothermal Therapy Generates Durable Treatment Responses in Neuroblastoma.Advanced healthcare materials · 2022Article
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe.Biomedical optics express · 2021Article
- Effective Treatment against ESBL-ProducingPharmaceutics · 2021Article
- Effective Photodynamic Therapy with Ir(III) for Virulent Clinical Isolates of Extended-Spectrum Beta-LactamasePharmaceutics · 2021Article
- Investigation of non-uniformly emitting optical fiber diffusers on the light distribution in tissue.Biomedical optics express · 2020Article
- Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.Photochemistry and photobiology · 2020Article
- Optimized Cylindrical Diffuser Powers for Interstitial PDT Breast Cancer Treatment Planning: A Simulation Study.BioMed research international · 2020Article
- Photodynamic Therapy for the Treatment of Glioblastoma.Frontiers in surgery · 2019Review
- Reconstruction of a Deformed Tumor Based on Fiducial Marker Registration: A Computational Feasibility Study.Technology in cancer research & treatment · 2018Article
- Interstitial Photodynamic Therapy-A Focused Review.Cancers · 2017Review
- Recovery of optical properties using interstitial cylindrical diffusers as source and detector fibers.Journal of biomedical optics · 2016Article
- Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review.Molecules (Basel, Switzerland) · 2016Review
- Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures.Journal of biomedical optics · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
purposeFor interstitial photodynamic therapy (iPDT) of bulky tumors, careful treatment planning is required in order to ensure that a therapeutic dose is delivered to the tumor, while minimizing damage to surrounding normal tissue. In clinical contexts, iPDT has typically been performed with either flat cleaved or cylindrical diffusing optical fibers as light sources. Here, the authors directly compare these two source geometries in terms of the number of fibers and duration of treatment required to deliver a prescribed light dose to a tumor volume.
methodsTreatment planning software for iPDT was developed based on graphics processing unit enhanced Monte Carlo simulations. This software was used to optimize the number of fibers, total energy delivered by each fiber, and the position of individual fibers in order to deliver a target light dose (D90) to 90% of the tumor volume. Treatment plans were developed using both flat cleaved and cylindrical diffusing fibers, based on tissue volumes derived from CT data from a head and neck cancer patient. Plans were created for four cases: fixed energy per fiber, fixed number of fibers, and in cases where both or neither of these factors were fixed.
resultsWhen the number of source fibers was fixed at eight, treatment plans based on flat cleaved fibers required each to deliver 7180-8080 J in order to deposit 90 J/cm(2) in 90% of the tumor volume. For diffusers, each fiber was required to deliver 2270-2350 J (333-1178 J/cm) in order to achieve this same result. For the case of fibers delivering a fixed 900 J, 13 diffusers or 19 flat cleaved fibers at a spacing of 1 cm were required to deliver the desired dose. With energy per fiber fixed at 2400 J and the number of fibers fixed at eight, diffuser fibers delivered the desired dose to 93% of the tumor volume, while flat cleaved fibers delivered this dose to 79%. With both energy and number of fibers allowed to vary, six diffusers delivering 3485-3600 J were required, compared to ten flat cleaved fibers delivering 2780-3600 J.
conclusionsFor the same number of fibers, cylindrical diffusers allow for a shorter treatment duration compared to flat cleaved fibers. For the same energy delivered per fiber, diffusers allow for the insertion of fewer fibers in order to deliver the same light dose to a target volume.
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