Evidence map›Paper›PMID 24506625›Full record

ArticleMedical physics2014

High energy x-ray phase contrast CT using glancing-angle grating interferometers.

A Sarapata, J W Stayman, M Finkenthal, J H Siewerdsen, F Pfeiffer, D Stutman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

A SarapataDepartment of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 and Department of Physics and Institute of Medical Engineering, Technische Universität München, 85748 Garching, Germany.
J W StaymanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218.
M FinkenthalDepartment of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218.
J H SiewerdsenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218.
F PfeifferDepartment of Physics and Institute of Medical Engineering, Technische Universität München, 85748 Garching, Germany.
D StutmanDepartment of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218.
Johns Hopkins University · USTechnical University of Munich · DE

Funding

Phase-contrast X-ray imaging system for large jointsR21EB012777 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI STUTMAN, DAN · 2011 to 2012
$407k
NIBIB NIH HHS 1R21EB012777-01A1NIBIB NIH HHS R21 EB012777
6 · The paper itself

Abstract

purposeThe authors present initial progress toward a clinically compatible x-ray phase contrast CT system, using glancing-angle x-ray grating interferometry to provide high contrast soft tissue images at estimated by computer simulation dose levels comparable to conventional absorption based CT.

methodsDPC-CT scans of a joint phantom and of soft tissues were performed in order to answer several important questions from a clinical setup point of view. A comparison between high and low fringe visibility systems is presented. The standard phase stepping method was compared with sliding window interlaced scanning. Using estimated dose values obtained with a Monte-Carlo code the authors studied the dependence of the phase image contrast on exposure time and dose.

resultsUsing a glancing angle interferometer at high x-ray energy (∼ 45 keV mean value) in combination with a conventional x-ray tube the authors achieved fringe visibility values of nearly 50%, never reported before. High fringe visibility is shown to be an indispensable parameter for a potential clinical scanner. Sliding window interlaced scanning proved to have higher SNRs and CNRs in a region of interest and to also be a crucial part of a low dose CT system. DPC-CT images of a soft tissue phantom at exposures in the range typical for absorption based CT of musculoskeletal extremities were obtained. Assuming a human knee as the CT target, good soft tissue phase contrast could be obtained at an estimated absorbed dose level around 8 mGy, similar to conventional CT.

conclusionsDPC-CT with glancing-angle interferometers provides improved soft tissue contrast over absorption CT even at clinically compatible dose levels (estimated by a Monte-Carlo computer simulation). Further steps in image processing, data reconstruction, and spectral matching could make the technique fully clinically compatible. Nevertheless, due to its increased scan time and complexity the technique should be thought of not as replacing, but as complimentary to conventional CT, to be used in specific applications.

Indexed as

HumansInterferometryMonte Carlo MethodPhantoms, ImagingRadiation DosageTomography, X-Ray Computed

Identifiers

PMID24506625
PMCPMC3981561
OpenAlexW1963565204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.