Evidence map›Paper›PMID 24505811›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2013

Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts.

Derrek P Hibar, Jason L Stein, Neda Jahanshad, Omid Kohannim, Arthur W Toga, Katie L McMahon, Greig I de Zubicaray, Grant W Montgomery, Nicholas G Martin, Margaret J Wright and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Reprint of: Mapping connectivity in the developing brain.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014
    Article
  6. Article
  7. Mapping connectivity in the developing brain.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Derrek P HibarImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Jason L SteinImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Neda JahanshadImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Omid KohannimImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Arthur W TogaImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.
Katie L McMahonCenter for Magnetic Resonance, School of Psychology, University of Queensland, Brisbane, Australia.
Greig I de ZubicarayFunctional Magnetic Resonance Imaging Laboratory, School of Psychology, University of Queensland, Brisbane, Australia.
Grant W MontgomeryGenetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Nicholas G MartinGenetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Margaret J WrightGenetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Michael W WeinerDepartment of Radiology, UC San Francisco, San Francisco, USA.
Paul M ThompsonImaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Empowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M
NIA NIH HHS U01 AG024904NIMH NIH HHS R01 MH097268
6 · The paper itself

Abstract

The SNP-SNP interactome has rarely been explored in the context of neuroimaging genetics mainly due to the complexity of conducting approximately 10(11) pairwise statistical tests. However, recent advances in machine learning, specifically the iterative sure independence screening (SIS) method, have enabled the analysis of datasets where the number of predictors is much larger than the number of observations. Using an implementation of the SIS algorithm (called EPISIS), we used exhaustive search of the genome-wide, SNP-SNP interactome to identify and prioritize SNPs for interaction analysis. We identified a significant SNP pair, rs1345203 and rs1213205, associated with temporal lobe volume. We further examined the full-brain, voxelwise effects of the interaction in the ADNI dataset and separately in an independent dataset of healthy twins (QTIM). We found that each additional loading in the epistatic effect was associated with approximately 5% greater brain regional brain volume (a protective effect) in both the ADNI and QTIM samples.

Indexed as

AlgorithmsAlzheimer DiseaseBrainChromosome MappingCohort StudiesConnectomeEpistasis, GeneticGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingOrgan SizePolymorphism, Single Nucleotide

Identifiers

PMID24505811
PMCPMC4109883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.