Evidence map›Paper›PMID 24505529›Full record

ArticleInternational journal of hematology-oncology and stem cell research2013

Poor platelet Count Response to Helicobacter Pylori Eradication in Patients with Severe Idiopathic Thrombocytopenic Purpura.

Mehrdad Payandeh, Dariyush Raeisi, Nasrollah Sohrabi, Mohammad Erfan Zare, Atefeh Nasir Kansestani, Nazanin Keshavarz, Samira Gholami, Amir Hossein Hashemian

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of hematology-oncology and stem cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Immune thrombocytopenic purpura secondary toProceedings (Baylor University. Medical Center) · 2022
    Article
  2. Effect ofBlood research · 2021
    Article
  3. AIMS microbiology · 2021
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mehrdad PayandehMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Dariyush RaeisiMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nasrollah SohrabiDepartment of Medical Laboratory Sciences, Para medicine Faculty, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad Erfan ZareMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Atefeh Nasir KansestaniMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nazanin KeshavarzStudent research committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Samira GholamiStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Amir Hossein HashemianDepartment of Biostatistics, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Kermanshah University of Medical Sciences · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionITP is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. The mechanisms of anti-platelet antibodies development are still a little known. The rate of some bacterial or viral agents in cause of ITP is well known. Recently, some study proposed that H pylori infection may be associated with ITP and H pylori eradication can improves platelet counts in infected ITP patients. MATERIALS AND

methodA baseline platelet count <50×10(3) µL for 4 weeks prior to study entry were required. These patients were tested for H. pylori infection by urea breath. All positive H pylori patients received triple therapy for 7 or 14 days to eradicate H pylori infection. These patients followed for six months.

resultsOf 92 patients with ITP, H pylori infection was found in 59.7% (55/92). After excluding patients with confounding factors, 41 patients were remained. After H pylori eradication, CR wasn't obtained in any patients. Partial response were obtained only in 3 (7.3%) of the 41 patients and no response in 38 (92.6%) patients. There is a significant difference between the platelet counts of PR and NR groups (P < 0.001).

conclusionThe results of this study and our previously study showed H pylori eradication therapy has beneficial effect for patients with mild thrombocytopenia but the chance of obtaining a response by H pylori treatment is lower in patients with severe thrombocytopenia.

Indexed as

Helicobacter pyloriIdiopathic thrombocytopenic purpuraPlatelet counts

Identifiers

PMID24505529
PMCPMC3913150
OpenAlexW2121858057

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.