Feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies.

Abdolreza Ardeshiry Lajimi, Majid Farshdousti Hagh, Najmaldin Saki, Esmaeil Mortaz, Masoud Soleimani, Fakher Rahim

Open access · greenAbstract readReview

In one paragraph

Review in International journal of hematology-oncology and stem cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it

0cells of the map it votes in

13citing papers in PubMed

2.4field-weighted citation impact, top 11% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis.Journal of translational medicine · 2018
Trial
Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies.International journal of molecular sciences · 2021
Review
Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders.Biomolecules & therapeutics · 2020
Review
A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells.Stem cells and cloning : advances and applications · 2018
Review
Feasibility and toxicity of hematopoietic stem cell transplant in multiple sclerosis.Iranian journal of basic medical sciences · 2017
Review
Thyroid Hormone Potentially Benefits Multiple Sclerosis via Facilitating Remyelination.Molecular neurobiology · 2016
Review
Immunomodulation in stem cell differentiation into neurons and brain repair.Stem cell reviews and reports · 2015
Review
Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis.International journal of molecular sciences · 2015
Review
Comparison of osteogenic differentiation potential of human adult stem cells loaded on bioceramic-coated electrospun poly (L-lactide) nanofibres.Cell proliferation · 2015
Article
Stem cell-based approach for the treatment of Parkinson's disease.Medical journal of the Islamic Republic of Iran · 2015
Review
Neuroprotective Effect of Transplanted Neural Precursors Embedded on PLA/CS Scaffold in an Animal Model of Multiple Sclerosis.Molecular neurobiology · 2015
Article
Comparison of random and aligned PCL nanofibrous electrospun scaffolds on cardiomyocyte differentiation of human adipose-derived stem cells.Iranian journal of basic medical sciences · 2014
Article
Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis.Annals of Indian Academy of Neurology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Abdolreza Ardeshiry LajimiStem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran.

Majid Farshdousti HaghDivision of Laboratory Hematology and Blood Banking, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Najmaldin SakiResearch Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Esmaeil MortazDivision of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands.

Masoud SoleimaniHematology Department, Faculty of Medical Science, Tarbiat modares University, Tehran, Iran.

Fakher RahimToxicology Research Center, Ahvaz Jundishapur, University of Medical Sciences, Ahvaz, Iran.

Ahvaz Jundishapur University of Medical Sciences · IRStem Cell Technology Research Center · IRUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple Sclerosis is an inflammatory disease of the central nervous system in which T cells experience a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. The recent advances in stem cell therapies may serve as potential treatments for neurological disorders. There are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. In this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of MS. These results may pave the road for the utilization of stem cells for the treatment of MS.

Indexed as

Hematopoietic stem cellsHuman embryonic stem cellsMesenchymal stem cellsMultiple sclerosisNeural stem cellsStem cells therapy

Identifiers

PMID24505515

PMCPMC3913133

OpenAlexW2100546793

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.