ArticleCommunicative & integrative biology2013
It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure.Progress in neurobiology · 2023Article
- The physical basis of mollusk shell chiral coiling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The genetic architecture of structural left-right asymmetry of the human brain.Nature human behaviour · 2021Article
- Altering metabolite distribution at Xenopus cleavage stages affects left-right gene expression asymmetries.Genesis (New York, N.Y. : 2000) · 2021Article
- Internet 'shellebrity' reflects on origin of rare mirror-image snails.Biology letters · 2020Article
- Miniaturized Filter-Aided Sample Preparation (MICRO-FASP) Method for High Throughput, Ultrasensitive Proteomics Sample Preparation Reveals Proteome Asymmetry inAnalytical chemistry · 2020Article
- HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner.Biology open · 2017Article
- The Zahn drawings: new illustrations ofDevelopment (Cambridge, England) · 2017Article
- Cilia in vertebrate left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Article
- Conserved roles for cytoskeletal components in determining laterality.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.Current biology : CB · 2016Article
- Cellular chirality arising from the self-organization of the actin cytoskeleton.Nature cell biology · 2015Article
- Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions.The International journal of developmental biology · 2014Article
- Physiological inputs regulate species-specific anatomy during embryogenesis and regeneration.Communicative & integrative biologyArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
For centuries, scientists and physicians have been captivated by the consistent left-right (LR) asymmetry of the heart, viscera, and brain. A recent study implicated tubulin proteins in establishing laterality in several experimental models, including asymmetric chemosensory receptor expression in C. elegans neurons, polarization of HL-60 human neutrophil-like cells in culture, and asymmetric organ placement in Xenopus. The same mutations that randomized asymmetry in these diverse systems also affect chirality in Arabidopsis, revealing a remarkable conservation of symmetry-breaking mechanisms among kingdoms. In Xenopus, tubulin mutants only affected LR patterning very early, suggesting that this axis is established shortly after fertilization. This addendum summarizes and extends the knowledge of the cytoskeleton's role in the patterning of the LR axis. Results from many species suggest a conserved role for the cytoskeleton as the initiator of asymmetry, and indicate that symmetry is first broken during early embryogenesis by an intracellular process.
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