ArticlePloS one2014
Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Can we distinguish respiratory viral infections based on clinical features? A prospective pediatric cohort compared to systematic literature review.Reviews in medical virology · 2018Pooled it
- Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials.Expert review of anti-infective therapy · 2017Pooled it
- Epidemiology, Genomic Diversity, and Evolutionary Dynamics of Human Metapneumovirus Over 7 Years of Integrated Community- and Hospital-Based Sentinel Surveillance in Senegal, 2018-2024.Influenza and other respiratory viruses · 2026Article
- Epidemiological trends and climate-driven dynamics of children respiratory infections in Lanzhou, China: a multi-pathogen time-series analysis.Frontiers in cellular and infection microbiology · 2026Article
- Epidemiological and phylogenetic characteristics of human metapneumovirus in Beijing, China, 2014-2024.Signal transduction and targeted therapy · 2025Article
- Incidence of Human Metapneumovirus Among Older Adults in 10 High-Income Countries: A Systematic Literature Review, Meta-analysis, and Modeling Study.Open forum infectious diseases · 2025Article
- Article
- A robust, scalable, and cost-efficient approach to whole genome sequencing of RSV directly from clinical samples.Journal of clinical microbiology · 2024Article
- Re-Emergence of HMPV in Gwangju, South Korea, after the COVID-19 Pandemic.Pathogens (Basel, Switzerland) · 2023Article
- Article
- Global Extension and Predominance of Human Metapneumovirus A2 Genotype with Partial G Gene Duplication.Viruses · 2022Article
- Virological Surveillance and Molecular Characterization of Human Parainfluenzavirus Infection in Children with Acute Respiratory Illness: Germany, 2015-2019.Microorganisms · 2021Article
- Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January - September 2020: Analysis of national surveillance data.The Lancet regional health. Europe · 2021Article
- Article
- The Prevalence and Genetic Characterization of Human Metapneumovirus in Bulgaria, 2016-2019.Intervirology · 2021Article
- Outbreak of Human Metapneumovirus Infection in Zoo, Slovenia.Emerging infectious diseases · 2020Article
- Clinical Features, Epidemiology, and Climatic Impact of Genotype-specific Human Metapneumovirus Infections: Long-term Surveillance of Hospitalized Patients in South Korea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Human metapneumovirus prevalence and patterns of subgroup persistence identified through surveillance of pediatric pneumonia hospital admissions in coastal Kenya, 2007-2016.BMC infectious diseases · 2019Article
- Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes.PloS one · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000-2001 and 2009-2010, HMPV was detected in 3% (138/4,549) of samples from outpatients with influenza-like illness with a new, sensitive real-time RT-PCR assay. Several hundred (797) clinical specimens from hospitalized children below the age of 4 years with acute respiratory illness were investigated and HMPV was detected in 11.9% of them. Investigation of outpatients revealed that HMPV infections occurred in individuals of all ages but were most prevalent in children (0-4 years) and the elderly (>60 years). The most present clinical features of HMPV infections were cough, bronchitis, fever/shivers and pneumonia. About two thirds of HMPV-positive samples were detected in February and March throughout the study period. Molecular characterization of HMPV revealed a complex cyclic pattern of group dominance where HMPV subgroup A and B viruses predominated in general for three consecutive seasons. German HMPV represented all genetic lineages including A1, A2, B1, B2, sub-clusters A2a and A2b. For Germany, not only time-dependent circulation of lineages and sub-clusters was observed but also co-circulation of two or three predominant lineages. Two newly emerging amino acid substitutions (positions 223 and 280) of lineage B2 were detected in seven German HMPV sequences. Our study gives new insights into the molecular epidemiology of HMPV in in- and outpatients over a time period of 10 years for the first time. It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide.
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