ArticlePloS one2014
Classification of non-small cell lung cancer based on copy number alterations.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- CNAttention: an attention-based deep multiple-instance method for uncovering copy number aberration signatures across cancers.Briefings in bioinformatics · 2026Article
- A fusion-based multiomics classification approach for enhanced gene discovery in non-small cell lung cancer.Bioinformatics advances · 2026Article
- Copy number variation heterogeneity reveals biological inconsistency in hierarchical cancer classifications.Molecular cytogenetics · 2024Article
- Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer.Journal of translational medicine · 2022Article
- CNVIntegrate: the first multi-ethnic database for identifying copy number variations associated with cancer.Database : the journal of biological databases and curation · 2021Article
- Article
- Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma.Genome medicine · 2020Article
- Identification and Analysis of Glioblastoma Biomarkers Based on Single Cell Sequencing.Frontiers in bioengineering and biotechnology · 2020Article
- The Methylation Pattern for Knee and Hip Osteoarthritis.Frontiers in cell and developmental biology · 2020Article
- Development of a risk scoring system for evaluating the prognosis of patients with Her2-positive breast cancer.Cancer cell international · 2020Article
- Identification and Analysis of the Blood lncRNA Signature for Liver Cirrhosis and Hepatocellular Carcinoma.Frontiers in genetics · 2020Article
- Integrative Analysis of Methylation and Gene Expression in Lung Adenocarcinoma and Squamous Cell Lung Carcinoma.Frontiers in bioengineering and biotechnology · 2020Article
- Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome.Cancers · 2019Article
- Smoking alters the evolutionary trajectory of non-small cell lung cancer.Experimental and therapeutic medicine · 2019Article
- A Shallow Convolutional Learning Network for Classification of Cancers Based on Copy Number Variations.Sensors (Basel, Switzerland) · 2019Article
- The early detection of asthma based on blood gene expression.Molecular biology reports · 2019Article
- Identification of the copy number variant biomarkers for breast cancer subtypes.Molecular genetics and genomics : MGG · 2019Article
- The Gene Expression Biomarkers for Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease.Frontiers in genetics · 2019Article
- The blood transcriptional signature for active and latent tuberculosis.Infection and drug resistance · 2019Article
- The transcriptome difference between colorectal tumor and normal tissues revealed by single-cell sequencing.Journal of Cancer · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is one of the leading causes of cancer mortality worldwide and non-small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In this study, we compared the genome-wide copy number alterations (CNAs) patterns of 208 early stage ACA and 93 early stage SCC tumor samples. As a result, 266 CNA probes stood out for better discrimination of ACA and SCC. It was revealed that the genes corresponding to these 266 probes were enriched in lung cancer related pathways and enriched in the chromosome regions where CNA usually occur in lung cancer. This study sheds lights on the CNA study of NSCLC and provides some insights on the epigenetic of NSCLC.
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