ArticlePloS one2014
Functional analysis of the tomato immune receptor Ve1 through domain swaps with its non-functional homolog Ve2.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- The C-terminal tail of Cf resistance proteins determines the intensity of the effector-triggered hypersensitive response-related cell death.Plant physiology · 2026Article
- The BrRLP1-BrMDAR1 module regulates the resistance to downy mildew in Brassica rapa.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling.Nature communications · 2025Article
- Functional Characterization ofMicrobiology spectrum · 2023Article
- Chromosome-level genome assembly of Mentha longifolia L. reveals gene organization underlying disease resistance and essential oil traits.G3 (Bethesda, Md.) · 2022Article
- Amplification of cell signaling and disease resistance by an immunity receptor Ve1Ve2 heterocomplex in plants.Communications biology · 2022Article
- Dynamic Tissue-Specific Transcriptome Changes in Response toPlants (Basel, Switzerland) · 2022Article
- Review
- Identification of Tomato Ve1 Homologous Proteins in Flax and Assessment for Race-Specific Resistance in Two Fiber FlaxCultivars againstPlants (Basel, Switzerland) · 2021Article
- An Overview of the Molecular Genetics of Plant Resistance to the Verticillium Wilt PathogenInternational journal of molecular sciences · 2020Review
- Antagonistic function of the Ve R-genes in tomato.Plant molecular biology · 2018Article
- Comparative RNA-Seq analysis reveals a critical role for brassinosteroids in rose (Rosa hybrida) petal defense against Botrytis cinerea infection.BMC genetics · 2018Article
- Tomato Ve resistance locus; defense or growth.Planta · 2018Article
- Transfer of tomato immune receptor Ve1 confers Ave1-dependent Verticillium resistance in tobacco and cotton.Plant biotechnology journal · 2018Article
- Host-induced gene silencing compromises Verticillium wilt in tomato and Arabidopsis.Molecular plant pathology · 2018Article
- Article
- Article
- Broad taxonomic characterization of Verticillium wilt resistance genes reveals an ancient origin of the tomato Ve1 immune receptor.Molecular plant pathology · 2017Article
- Large-scale transcriptome comparison of sunflower genes responsive to Verticillium dahliae.BMC genomics · 2017Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance in tomato against race 1 strains of the fungal vascular wilt pathogens Verticillium dahliae and V. albo-atrum is mediated by the Ve locus. This locus comprises two closely linked inversely oriented genes, Ve1 and Ve2, which encode cell surface receptors of the extracellular leucine-rich repeat receptor-like protein (eLRR-RLP) type. While Ve1 mediates Verticillium resistance through monitoring the presence of the recently identified V. dahliae Ave1 effector, no functionality for Ve2 has been demonstrated in tomato. Ve1 and Ve2 contain 37 eLRRs and share 84% amino acid identity, facilitating investigation of Ve protein functionality through domain swapping. In this study it is shown that Ve chimeras in which the first thirty eLRRs of Ve1 were replaced by those of Ve2 remain able to induce HR and activate Verticillium resistance, and that deletion of these thirty eLRRs from Ve1 resulted in loss of functionality. Also the region between eLRR30 and eLRR35 is required for Ve1-mediated resistance, and cannot be replaced by the region between eLRR30 and eLRR35 of Ve2. We furthermore show that the cytoplasmic tail of Ve1 is required for functionality, as truncation of this tail results in loss of functionality. Moreover, the C-terminus of Ve2 fails to activate immune signaling as chimeras containing the C-terminus of Ve2 do not provide Verticillium resistance. Furthermore, Ve1 was found to interact through its C-terminus with the eLRR-containing receptor-like kinase (eLRR-RLK) interactor SOBIR1 that was recently identified as an interactor of eLRR-RLP (immune) receptors. Intriguingly, also Ve2 was found to interact with SOBIR1.
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