Evidence map›Paper›PMID 24505411›Full record

SynthesisPloS one2014

Text message intervention designs to promote adherence to antiretroviral therapy (ART): a meta-analysis of randomized controlled trials.

David J Finitsis, Jennifer A Pellowski, Blair T Johnson

5 registry-linked trialsOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 239 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 19 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02707991 nacompletednot on this mapstarted 2016, after this paper: background citation

Nurse Case Management to Improve Linkage to Hepatitis C Care and Treatment Initiation in HIV Co-infection: A Randomized Controlled Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2016 to 2018Enrolled68ConditionsHIV, Hepatitis C, ChronicArmsNurse Case Management
NCT03584282 nacompletednot on this mapstarted 2018, after this paper: background citation

Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users

TypeinterventionalSponsorUniversity of WashingtonRan2018 to 2022Enrolled21ConditionsHIV/AIDS, Adherence, Medication, Drug UseArmsText Messaging, Peer Navigation
NCT03928418 nacompletednot on this mapstarted 2019, after this paper: background citation

Mobile Technology to Extend Clinic-based Counseling for HIV+s in Uganda

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2021Enrolled272ConditionsAlcohol Use, Unspecified, HIV/AIDSArmsIn-person counseling session, Live phone call booster session, Technology (IVR or SMS) booster session
NCT04119375 nacompletednot on this mapstarted 2018, after this paper: background citation

Behavior Change and Digital Health Interventions for Improved TB Treatment Outcomes: a RCT

TypeinterventionalSponsorMassachusetts Institute of TechnologyRan2018 to 2021Enrolled16,146ConditionsTuberculosis, Adherence, Patient, Adherence, Medication, Drug-resistant TuberculosisArmsKeheala Mobile Health Platform and Behavioral Interventions, Social and Behavior Change Communication (SBCC), SMS Reminder, Standard of Care
NCT04616612 nacompletednot on this mapstarted 2021, after this paper: background citation

Medication Adherence Given Individual SystemCHANGE(TM) in Advancing Nephropathy (MAGICIAN) Pilot Study

TypeinterventionalSponsorIndiana UniversityRan2021 to 2024Enrolled150ConditionsChronic Kidney Disease(CKD)ArmsSystemCHANGE (TM), Attention Control
3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 19 syntheses or guidelines pooled it, 391 citations in OpenAlex.

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179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David J FinitsisDepartment of Psychology, Center for Health, Intervention, & Prevention (CHIP), University of Connecticut, Storrs, Connecticut, United States of America.
Jennifer A PellowskiDepartment of Psychology, Center for Health, Intervention, & Prevention (CHIP), University of Connecticut, Storrs, Connecticut, United States of America.
Blair T JohnsonDepartment of Psychology, Center for Health, Intervention, & Prevention (CHIP), University of Connecticut, Storrs, Connecticut, United States of America.
University of Connecticut · US

Funding

SYNTHESES OF HIV RISK REDUCTION RESEARCHR01MH058563 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI JOHNSON, BLAIR T · 1998 to 2013
$5.2M
Training in Social Processes of HIV/AIDST32MH074387 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2006 to 2020
$3.9M
NIMH NIH HHS R01 MH058563NIMH NIH HHS R01-MH58563NIMH NIH HHS T32 MH074387NIMH NIH HHS T32-MH074387
6 · The paper itself

Abstract

backgroundThe efficacy of antiretroviral therapy depends on patient adherence to a daily medication regimen, yet many patients fail to adhere at high enough rates to maintain health and reduce the risk of transmitting HIV. Given the explosive global growth of cellular-mobile phone use, text-messaging interventions to promote adherence are especially appropriate. This meta-analysis synthesized available text messaging interventions to promote antiretroviral therapy adherence in people living with HIV.

methodsWe performed Boolean searches of electronic databases, hand searches of recent year conference abstracts and reverse searches. Included studies (1) targeted antiretroviral therapy adherence in a sample of people living with HIV, (2) used a randomized-controlled trial design to examine a text messaging intervention, and (3) reported at least one adherence measurement or clinical outcome.

resultsEight studies, including 9 interventions, met inclusion criteria. Text-messaging interventions yielded significantly higher adherence than control conditions (OR = 1.39; 95% CI = 1.18, 1.64). Sensitivity analyses of intervention characteristics suggested that studies had larger effects when interventions (1) were sent less frequently than daily, (2) supported bidirectional communication, (3) included personalized message content, and (4) were matched to participants' antiretroviral therapy dosing schedule. Interventions were also associated with improved viral load and/or CD4+ count (k = 3; OR = 1.56; 95% CI = 1.11, 2.20).

conclusionsText-messaging can support antiretroviral therapy adherence. Researchers should consider the adoption of less frequent messaging interventions with content and timing that is individually tailored and designed to evoke a reply from the recipient. Future research is needed in order to determine how best to optimize efficacy.

Indexed as

Patient ComplianceText MessagingAnti-HIV AgentsHIV InfectionsHumansRandomized Controlled Trials as TopicReminder SystemsTreatment OutcomeAnti-HIV Agents

Identifiers

PMID24505411
PMCPMC3914915
OpenAlexW1991341312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.