ArticlePloS one2014
Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- The circulation of methicillin-resistant Staphylococcus aureus between humans, horses and the environment at the equine clinic.The Journal of antimicrobial chemotherapy · 2024Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Colonization of Dogs and Their Owners withMicroorganisms · 2022Article
- Prevalence and WGS-based characteristics of Staphylococcus aureus in the nasal mucosa and pastern of horses with equine pastern dermatitis.BMC veterinary research · 2022Article
- Methicillin-Resistant Staphylococcus aureus Strains in Swiss Pigs and Their Relation to Isolates from Farmers and Veterinarians.Applied and environmental microbiology · 2020Article
- Article
- Molecular Characterization of EquineToxins · 2019Article
- Article
- Identification of a staphylococcal complement inhibitor with broad host specificity in equidThe Journal of biological chemistry · 2018Article
- Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016.Scientific reports · 2017Article
- Recombination-Mediated Host Adaptation by Avian Staphylococcus aureus.Genome biology and evolution · 2017Article
- Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.Scientific reports · 2017Article
- Molecular Epidemiology of Methicillin-ResistantFrontiers in microbiology · 2017Article
- Horses in Denmark Are a Reservoir of Diverse Clones of Methicillin-Resistant and -SusceptibleFrontiers in microbiology · 2017Article
- Methicillin-resistantOne health (Amsterdam, Netherlands) · 2016Article
- Livestock-Associated Methicillin ResistantFrontiers in microbiology · 2016Article
- Livestock-Associated MRSA: The Impact on Humans.Antibiotics (Basel, Switzerland) · 2015Review
- Methicillin-resistantVeterinary medicine (Auckland, N.Z.) · 2015Review
Corrections and comments
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Authors and funding
20 authors at 11 institutions in 8 countries.
Funding
Abstract
In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the population structure of CC398 through mutation discovery at 97 genetic housekeeping loci, which are distributed along the CC398 chromosome within 195 CC398 isolates, collected from various countries and host species, including humans. Most of the isolates in this collection were received from collaborating microbiologists, who had preserved them over years. We discovered 96 bi-allelic polymorphisms, and phylogenetic analyses revealed that an epidemic sub-clone within CC398 (dubbed 'clade (C)') has spread within and between equine hospitals, where it causes nosocomial infections in horses and colonises the personnel. While clade (C) was strongly associated with S. aureus from horses in veterinary-care settings (p = 2 × 10(-7)), it remained extremely rare among S. aureus isolates from human infections.
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