Evidence map›Paper›PMID 24505291›Full record

SynthesisPloS one2014

Associations of MTHFR gene polymorphisms with hypertension and hypertension in pregnancy: a meta-analysis from 114 studies with 15411 cases and 21970 controls.

Boyi Yang, Shujun Fan, Xueyuan Zhi, Yongfang Li, Yuyan Liu, Da Wang, Miao He, Yongyong Hou, Quanmei Zheng, Guifan Sun

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 10 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 10 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Polymorphism rs1801516 (G > A) in theThe Journal of international medical research · 2020
    Pooled it
  3. TheThe Journal of international medical research · 2020
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  17. Susceptibility to hypertension based onFrontiers in cardiovascular medicine · 2023
    Article
  18. Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Boyi YangEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Shujun FanEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Xueyuan ZhiEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Yongfang LiEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Yuyan LiuEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Da WangEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Miao HeEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Yongyong HouDepartment of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America.
Quanmei ZhengEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
Guifan SunEnvironment and Non-Communicable Diseases Research Center, School of Public Health, China Medical University, Shenyang, China.
China Medical University · CNIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral epidemiological studies have investigated the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with hypertension (H) or hypertension in pregnancy (HIP). However, the results were controversial. We therefore performed a comprehensive meta-analysis to provide empirical evidences on the associations. METHODOLOGIES: The English and Chinese databases were systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, sensitivity analysis, cumulative meta-analysis and assessment of publication bias were performed in our study. PRINCIPAL

findingsA total of 114 studies with 15411 cases and 21970 controls were included, 111 studies with 15094 cases and 21633 controls for the C677T polymorphism and 21 with 2533 cases and 2976 controls for the A1298C polymorphism. Overall, the C677T polymorphism was significantly associated with H and HIP (H & HIP: OR = 1.26, 95% CI = 1.17-1.34; H: OR = 1.36, 95% CI = 1.20-1.53; HIP: OR = 1.21, 95% CI = 1.08-1.32). Stratified analysis by ethnicity revealed a significant association among East Asians and Caucasians, but not among Latinos, Black Africans, and Indians and Sri Lankans. In the stratified analyses according to source of controls, genotyping method, sample size and study quality, significant associations were observed in all the subgroups, with the exception of population based subgroup in H studies and large sample size and "others" genotyping method subgroups in HIP studies. For the A1298C polymorphism, no significant association was observed either in overall or subgroup analysis under all genetic models.

conclusionsThis meta-analysis suggests that the MTHFR C677T rather than A1298C polymorphism may be associated with H & HIP, especially among East Asians and Caucasians.

Indexed as

Polymorphism, GeneticAsian PeopleFemaleHumansHypertension, Pregnancy-InducedMethylenetetrahydrofolate Reductase (NADPH2)PregnancyWhite PeopleMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID24505291
PMCPMC3914818
OpenAlexW2122029623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.