ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Coil Sketching for Fast and Efficient 4D Lung MRI Reconstruction.Magnetic resonance in medicine · 2026Article
- Vaping causes an acute BMI-dependent change in pulmonary blood flow.Physiological reports · 2024Article
- Improving asthma outcomes: Clinicians' perspectives on peripheral airways.The journal of allergy and clinical immunology. Global · 2024Article
- Assessing the pulmonary vascular responsiveness to oxygen with proton MRI.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test.Scientific reports · 2021Article
- Vaping disrupts ventilation-perfusion matching in asymptomatic users.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Breathing freely during nitrogen washout.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches.Comprehensive Physiology · 2020Review
- Ventilation-perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% OPhysiological reports · 2020Article
- Heavy upright exercise increases ventilation-perfusion mismatch in the basal lung: indirect evidence for interstitial pulmonary edema.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent.Journal of visualized experiments : JoVE · 2019Article
- The spatial pattern of methacholine bronchoconstriction recurs when supine independently of posture during provocation but does not recur between postures.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Comparison of quantitative multiple-breath specific ventilation imaging using colocalized 2D oxygen-enhanced MRI and hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Treatment planning based on lung functional avoidance is not ready for clinical deployment.Medical physics · 2018Article
- Spatial persistence of reduced specific ventilation following methacholine challenge in the healthy human lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Pulmonary Delivery of Therapeutic and Diagnostic Gases.Journal of aerosol medicine and pulmonary drug delivery · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Specific ventilation imaging (SVI) uses proton MRI to quantitatively map the distribution of specific ventilation (SV) in the human lung, using inhaled oxygen as a contrast agent. To validate this recent technique, we compared the quantitative measures of heterogeneity of the SV distribution in a 15-mm sagittal slice of lung obtained in 10 healthy supine subjects, (age 37 ± 10 yr, forced expiratory volume in 1 s 97 ± 7% predicted) using SVI to those obtained in the whole lung from multiple-breath nitrogen washout (MBW). Using the analysis of Lewis et al. (Lewis SM, Evans JW, Jalowayski AA. J App Physiol 44: 416-423, 1978), the most likely distribution of SV from the MBW data was computed and compared with the distribution of SV obtained from SVI, after normalizing for the difference in tidal volume. The average SV was 0.30 ± 0.10 MBW, compared with 0.36 ± 0.10 SVI (P = 0.01). The width of the distribution, a measure of the heterogeneity, obtained using both methods was comparable: 0.51 ± 0.06 and 0.47 ± 0.08 in MBW and SVI, respectively (P = 0.15). The MBW estimated width of the SV distribution was 0.05 (10.7%) higher than that estimated using SVI, and smaller than the intertest variability of the MBW estimation [inter-MBW (SD) for the width of the SV distribution was 0.08 (15.8)%]. To assess reliability, SVI was performed twice on 13 subjects showing small differences between measurements of SV heterogeneity (typical error 0.05, 12%). In conclusion, quantitative estimations of SV heterogeneity from SVI are reliable and similar to those obtained using MBW, with SVI providing spatial information that is absent in MBW.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.