ReviewJournal of muscle research and cell motility2014
The role of satellite cells in muscle hypertrophy.
Review in Journal of muscle research and cell motility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage.The Journal of physiology · 2017Trial
- Effect of Amino Acid Derivatives and Polyphenol Supplementation on Ovine Muscle Growth In Vitro and In Vivo.Muscles (Basel, Switzerland) · 2026Article
- Skeletal Muscle Memory: An Update From the Antidoping Perspective.Drug testing and analysis · 2025Review
- Probiotics Attenuate Myopathic Changes in Aging Rats via Activation of the Myogenic Stellate Cells.Probiotics and antimicrobial proteins · 2025Article
- Molecular aspects of the exercise response and training adaptation in skeletal muscle.Free radical biology & medicine · 2024Review
- Developing engineered muscle tissues utilizing standard cell culture plates and mesenchymal stem cell-conditioned medium.Regenerative therapy · 2024Article
- Effects of the purified dry extract of fermented ginseng BST204 on muscle fiber regeneration.Biochemistry and biophysics reports · 2023Article
- Resistance exercise: a mighty tool that adapts, destroys, rebuilds and modulates the molecular and structural environment of skeletal muscle.Physical activity and nutrition · 2023Article
- LncRNAs as a new regulator of chronic musculoskeletal disorder.Cell proliferation · 2021Review
- Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity.Cell reports · 2021Article
- Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy.Molecular metabolism · 2020Article
- Physical activity and exercise: Strategies to manage frailty.Redox biology · 2020Review
- Edward F. Adolph Distinguished Lecture. Skeletal muscle atrophy: Multiple pathways leading to a common outcome.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Review
- Satellite cells in ageing: use it or lose it.Open biology · 2020Review
- Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats.Journal of cellular and molecular medicine · 2020Article
- Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep.The Journal of endocrinology · 2019Article
- Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells.Biochemistry and biophysics reports · 2019Article
- Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production.Cells · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of satellite cells in muscle hypertrophy has long been a debated issue. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis, giving rise to the idea of a nuclear domain. This, together with the observation that during various models of muscle hypertrophy there is an activation of the muscle stem cells, i.e. satellite cells, lead to the idea that satellite cell activation is required for muscle hypertrophy. Thus, satellite cells are not only responsible for muscle repair and regeneration, but also for hypertrophic growth. Further support for this line of thinking was obtained after studies showing that irradiation of skeletal muscle, and therefore elimination of all satellite cells, completely prevented overload-induced hypertrophy. Recently however, using different transgenic approaches, it has become clear that muscle hypertrophy can occur without a contribution of satellite cells, even though in most situations of muscle hypertrophy satellite cells are activated. In this review we will discuss the contribution of satellite cells, and other muscle-resident stem cells, to muscle hypertrophy both in mice as well as in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.