ArticleWorld journal of urology2015
Clinical and pathological outcomes of renal cell carcinoma (RCC) in native kidneys of patients with end-stage renal disease: a long-term comparative retrospective study with RCC diagnosed in the general population.
Article in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
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- Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer.International journal of molecular sciences · 2023Review
- Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets.International journal of molecular sciences · 2022Review
- Outcome of advanced renal cell carcinoma arising in end-stage renal disease: comparison with sporadic renal cell carcinoma.Clinical and experimental nephrology · 2021Article
- Outcomes of arteriovenous access among cancer patients requiring chronic haemodialysis.BMC nephrology · 2020Observational
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- Clinical features and outcomes in kidney transplant recipients with renal cell carcinoma: a single-center study.Kidney research and clinical practice · 2019Article
- Ipsilateral synchronous clear and papillary renal cell carcinoma: A case report and review of the literature.Urology case reports · 2018Article
- Prognostic Factors for Renal Cell Carcinoma Subtypes Diagnosed According to the 2016 WHO Renal Tumor Classification: a Study Involving 928 Patients.Pathology oncology research : POR · 2017Article
- Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma.Oncotarget · 2017Article
- Multi-omics approach reveals the secrets of metabolism of clear cell-renal cell carcinoma.Translational andrology and urology · 2016Article
- Review of renal cell carcinoma and its common subtypes in radiology.World journal of radiology · 2016Review
- Intrinsic Genomic Differences Between African American and White Patients With Clear Cell Renal Cell Carcinoma.JAMA oncology · 2016Article
- Multimodality Imaging Characteristics of the Common Renal Cell Carcinoma Subtypes: An Analysis of 544 Pathologically Proven Tumors.Journal of clinical imaging science · 2016Article
- Observational
- Comparison of prognosis between patients with renal cell carcinoma on hemodialysis and those with renal cell carcinoma in the general population.International journal of clinical oncology · 2015Article
- Clinicopathological characteristics of surgically treated localized renal masses in patients previously exposed to chemotherapy.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
- Erratum issuedErratum to: Clinical and pathological outcomes of renal cell carcinoma (RCC) in native kidneys of patients with end-stage renal disease: a long-term comparative retrospective study with RCC diagnosed in the general population.2015 · Luccarelli, Giuseppe [corrected to Lucarelli, Giuseppe]
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with end-stage renal disease (ESRD) have an increased risk of developing renal cell carcinoma (RCC). This retrospective study compared clinical and pathological outcomes of RCC occurring in native kidneys of patients with ESRD (whether they underwent kidney transplantation or not) with those of renal tumors diagnosed in the general population.
methodsThe study included a total of 533 patients with RCC. The ESRD cohort included 92 patients with RCC in native kidneys. Of these, 58 and 34 cases were identified before (pre-Tx group) and after kidney transplantation (post-Tx group), respectively. The control group was composed of 441 RCCs diagnosed in the general population. Variables were compared by chi-square and Student's t tests. Cancer-specific survival was assessed by Kaplan-Meier and Cox methods.
resultsThe ESRD groups had smaller (P = 0.001), lower-grade, and lower-stage tumors than the non-ESRD group (P = 0.001). The papillary RCC rate was higher in the ESRD groups (P = 0.01). Ten-year cancer-specific survivals were 94.5, 87.9, and 74.6 % in pre-Tx, post-Tx, and non-ESRD patients, respectively (P = 0.003). Mean follow-up was 90.2 months. At multivariate analysis, tumor size (HR = 1.10), pathological stage (HR = 1.46), presence of nodal (HR = 2.22) and visceral metastases (HR = 3.49), and Fuhrman grade (HR = 1.48) were independent adverse prognostic factors for cancer-specific survival.
conclusionsNative kidney RCCs arising in ESRD patients are lower stage and lower grade as compared to RCCs diagnosed in the general population, and these tumors exhibit favorable clinical and outcome features.
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