ArticlePlant cell reports2014
Balanced activity of microRNA166/165 and its target transcripts from the class III homeodomain-leucine zipper family regulates root growth in Arabidopsis thaliana.
Article in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Epigenomics as Potential Tools for Enhancing Magnitude of Breeding Approaches for Developing Climate Resilient Chickpea.Frontiers in genetics · 2022Pooled it
- Mobile small RNAs as mediators of stress-induced epigenomic remodeling and systemic stress adaptation.Frontiers in epigenetics and epigenomics · 2026Review
- Domain characteristics, classification and expression profiles in response to various abiotic stresses of four HD-Zip subfamilies in tea plant.BMC plant biology · 2025Article
- An integrated analysis of miRNA and mRNA expressions in soybean response to boron stress.PloS one · 2025Article
- Review
- Knockdown of microRNA390 Enhances Maize Brace Root Growth.International journal of molecular sciences · 2024Article
- An AGO10:miR165/6 module regulates meristem activity and xylem development in the Arabidopsis root.The EMBO journal · 2024Article
- Mechanism of action of microRNA166 on nitric oxide in alfalfa (Medicago sativa L.) under drought stress.BMC genomics · 2024Article
- Characterization of VvmiR166s-Target Modules and Their Interaction Pathways in Modulation of Gibberellic-Acid-Induced Grape Seedless Berries.International journal of molecular sciences · 2023Article
- Conserved and non-conserved RNA-target modules in plants: lessons for a better understanding of Marchantia development.Plant molecular biology · 2023Review
- The genome of the Wollemi pine, a critically endangered "living fossil" unchanged since the Cretaceous, reveals extensive ancient transposon activity.bioRxiv : the preprint server for biology · 2023Article
- The miR166d/International journal of molecular sciences · 2023Article
- Differential Responses of Wheat (Frontiers in plant science · 2022Article
- The sly-miR166-SlyHB module acts as a susceptibility factor during ToLCNDV infection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Conservation and Diversity of miR166 Family Members From Highbush Blueberry (Frontiers in genetics · 2022Article
- Core RNA Interference Genes Involved in miRNA and Ta-siRNA Biogenesis in Hops and Their Expression Analysis after Challenging withInternational journal of molecular sciences · 2021Article
- Photocontrol of Axillary Bud Outgrowth by MicroRNAs: Current State-of-the-Art and Novel Perspectives Gained From the Rosebush Model.Frontiers in plant science · 2021Article
- RNAi Mediated Hypoxia Stress Tolerance in Plants.International journal of molecular sciences · 2020Review
- Genome-wide characterization and expression profiling of Eucalyptus grandis HD-Zip gene family in response to salt and temperature stress.BMC plant biology · 2020Article
- Molecular and Hormonal Regulation of Leaf Morphogenesis in Arabidopsis.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of miR166/165 down-regulates target HD - ZIP IIIs and promotes root growth by enhancing cell division and meristematic activity, whereas overexpression of HD - ZIP IIIs inhibits root growth in Arabidopsis thaliana. Post-embryonic growth of higher plants is maintained by active meristems harbouring undifferentiated cells. Shoot and root apical meristems (SAM and RAM) utilize both similar and distinct signalling mechanisms for their maintenance in Arabidopsis thaliana. An important regulatory role in this context has the interaction of microRNAs with their target mRNAs, mostly encoding transcription factors. One class of microRNA166/165 (miR166/165) has been implicated in the maintenance of SAM and vascular patterning. Here, we show that miR166/165 plays an important role in root growth also by negatively regulating its target transcripts, HD-ZIP IIIs, in the RAM. While overexpression of miR166 promotes RAM activity, overexpression of its targets reduces RAM activity. These results reveal a conserved role of miR166/165 in the maintenance of SAM and RAM activity in A. thaliana.
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Registered trials
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