Evidence map›Paper›PMID 24504435›Full record

ArticleCancer causes & control : CCC2014

Physical activity and prostate gene expression in men with low-risk prostate cancer.

Mark Jesus M Magbanua, Erin L Richman, Eduardo V Sosa, Lee W Jones, Jeff Simko, Katsuto Shinohara, Christopher M Haqq, Peter R Carroll, June M Chan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

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  11. Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
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  14. Reductive stress in striated muscle cells.Cellular and molecular life sciences : CMLS · 2020
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  17. Vigorous Physical Activity Is Associated with Lower Risk of Metastatic-Lethal Progression in Prostate Cancer and Hypomethylation in theCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mark Jesus M MagbanuaDivision of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.
Erin L Richman
Eduardo V Sosa
Lee W Jones
Jeff Simko
Katsuto Shinohara
Christopher M Haqq
Peter R Carroll
June M Chan
University of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · USDuke Medical Center · US

Funding

Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
Molecular Effects of Nutrition Supplements in ProstateR01CA101042 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARROLL, PETER R · 2003 to 2007
$1.7M
NCI NIH HHS R01 CA101042NCI NIH HHS R01CA101042NCI NIH HHS R25 CA112355NCI NIH HHS R25CA112355
6 · The paper itself

Abstract

purposeVigorous physical activity after diagnosis of localized prostate cancer may reduce the risk of disease progression and prostate cancer-specific mortality. The molecular mechanisms by which physical activity may exert protective effects in the prostate remain unknown.

methodsWe examined the associations between self-reported physical activity and gene expression patterns in morphologically normal prostate tissue of 71 men with low-risk prostate cancer on active surveillance. Differential gene expression, gene set, and pathway analyses were conducted comparing dichotomous groups defined by type, intensity, and amount of physical activity reported.

resultsCell cycling and DNA repair pathways were up-regulated in men who participated in ≥ 3 h/week vigorous activity compared with men who did not. In addition, canonical pathways involved in cell signaling and metabolism, the cellular effects of sildenafil (Viagra), and the Nrf2-mediated oxidative stress response were modulated in men who reported ≥ 3 h/week of vigorous activity. Differential expression analysis at the individual gene level revealed modest differences between men who performed vigorous activity for ≥ 3 h/week and those who did not. There were no differences in prostate gene expression in comparisons with exercise groupings that did not consider both duration and intensity of activity.

conclusionsProstate gene expression and pathway analyses revealed sets of transcripts that may be modulated in normal prostate tissue by participating in ≥ 3 h/week of vigorous activity after diagnosis of low-risk prostate cancer. These findings suggest potential biological mechanisms by which vigorous activity may reduce risk of prostate cancer progression and warrant further study and validation.

Indexed as

Gene ExpressionGene Expression ProfilingHumansMaleMiddle AgedMotor ActivityProstatic NeoplasmsRandomized Controlled Trials as TopicSelf ReportTranscriptome

Identifiers

PMID24504435
PMCPMC3990413
OpenAlexW2066746433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.