ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2014
Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Hypoxia tolerance of intertidal triplefin fish is associated with low critical oxygen tension and high phosphorylating capacity in brain mitochondria.Scientific reports · 2026Article
- Low oxidative stress during mitochondrial recovery from anoxia in Artemia franciscana, an invertebrate extremophile.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Effects of hypoxia-reoxygenation on the bioenergetics and oxidative stress in the isolated mitochondria of the king scallop, Pecten maximus.The Journal of experimental biology · 2025Article
- The cardiac response of the goldfish Carassius auratus to environmental hypoxia: from hemodynamics to mitochondria.Fish physiology and biochemistry · 2025Article
- Mitochondrial responses to constant and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve Crassostrea gigas.Scientific reports · 2024Article
- Effect of dissolved oxygen and ammonia nitrogen onHeliyon · 2024Article
- Functional, structural, and molecular remodelling of the goldfish (Carassius auratus) heart under moderate hypoxia.Fish physiology and biochemistry · 2024Article
- Torpid 13-lined ground squirrel liver mitochondria resist anoxia-reoxygenation despite high levels of protein damage.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Succinate-mediated reactive oxygen species production in the anoxia-tolerant epaulette (Biology letters · 2023Article
- Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas.The Journal of experimental biology · 2023Article
- Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.The Journal of experimental biology · 2023Article
- New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.Acta physiologica (Oxford, England) · 2022Review
- Differential regulation of degradation and immune pathways underlies adaptation of the ectosymbiotic nematode Laxus oneistus to oxic-anoxic interfaces.Scientific reports · 2022Article
- The Long-Term Effects of Developmental Hypoxia on Cardiac Mitochondrial Function in Snapping Turtles.Frontiers in physiology · 2021Article
- Genome-Wide Association Analysis of Anoxia Tolerance inG3 (Bethesda, Md.) · 2019Article
- Acute hypoxia/reoxygenation affects muscle mitochondrial respiration and redox state as well as swimming endurance in zebrafish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex IThe Journal of experimental biology · 2018Article
- Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals.Frontiers in physiology · 2018Review
- Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrion plays a critical role in the development of Oxygen (O2)-related diseases. While research has predominantly focused on hypoxia-sensitive mammals as surrogates for humans, the use of animals which have naturally evolved anoxia tolerance has been largely ignored. Remarkably, some animals can live in the complete absence of O2 for days, months and even years, but surprisingly little is currently known about mitochondrial function in these species. In contrast to mammals, mitochondrial function in anoxia-tolerant animals is relatively insensitive to in vitro anoxia and reoxygenation, suggesting that anoxia tolerance transcends to the level of the mitochondria. Furthermore, long-term anoxia is associated with marked changes in the intrinsic properties of the mitochondria from these species, which may afford protection against anoxia-related damage. In the present review, we highlight some of the strategies anoxia-tolerant animals possess to preserve mitochondrial function in the absence of O2. Specifically, we review mitochondrial Ca(2+) regulation, proton leak, redox signaling and mitochondrial permeability transition, in phylogenetically diverse groups of anoxia-tolerant animals. From the strategies they employ, these species emerge as model organisms to illuminate novel interventions to mitigate O2-related mitochondrial dysfunction in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.