ArticleGenetics2014
Causes and consequences of genetic background effects illuminated by integrative genomic analysis.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 66 citations in OpenAlex.
- Efficient RFLP-based Protocol for Routine Authentication of Drosophila.microPublication biology · 2026Article
- Interaction of genetic variants activates latent metabolic pathways in yeast.Nature communications · 2025Article
- Genome-wide impact of codon usage bias on translation optimization in Drosophila melanogaster.Nature communications · 2024Article
- Genome-scale analysis of interactions between genetic perturbations and natural variation.Nature communications · 2024Article
- Genome-scale analysis of interactions between genetic perturbations and natural variation.bioRxiv : the preprint server for biology · 2024Article
- Mousepost 2.0, a major expansion of the resource.Nucleic acids research · 2023Article
- The genetic basis of adaptation to copper pollution inFrontiers in genetics · 2023Article
- Article
- Allopatric divergence of cooperators confers cheating resistance and limits effects of a defector mutation.BMC ecology and evolution · 2022Article
- Loss-of-function mutation survey revealed that genes with background-dependent fitness are rare and functionally related in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetic basis of a spontaneous mutation's expressivity.Genetics · 2022Article
- Decoding 'Unnecessary Complexity': A Law of Complexity and a Concept of Hidden Variation Behind "Missing Heritability" in Precision Medicine.Journal of molecular evolution · 2021Review
- Molecular competition can shape enhancer activity in theiScience · 2021Article
- Natural variants suppress mutations in hundreds of essential genes.Molecular systems biology · 2021Article
- The complex role of genetic background in shaping the effects of spontaneous and induced mutations.Yeast (Chichester, England) · 2021Review
- Increased diagnostic and new genes identification outcome using research reanalysis of singleton exome sequencing.European journal of human genetics : EJHG · 2019Article
- Article
- Complex modifier landscape underlying genetic background effects.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Effects of stable ectopic expression of the primary sex determination gene Yob in the mosquito Anopheles gambiae.Parasites & vectors · 2018Article
- The complex underpinnings of genetic background effects.Nature communications · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypic consequences of individual mutations are modulated by the wild-type genetic background in which they occur. Although such background dependence is widely observed, we do not know whether general patterns across species and traits exist or about the mechanisms underlying it. We also lack knowledge on how mutations interact with genetic background to influence gene expression and how this in turn mediates mutant phenotypes. Furthermore, how genetic background influences patterns of epistasis remains unclear. To investigate the genetic basis and genomic consequences of genetic background dependence of the scalloped(E3) allele on the Drosophila melanogaster wing, we generated multiple novel genome-level datasets from a mapping-by-introgression experiment and a tagged RNA gene expression dataset. In addition we used whole genome resequencing of the parental lines-two commonly used laboratory strains-to predict polymorphic transcription factor binding sites for SD. We integrated these data with previously published genomic datasets from expression microarrays and a modifier mutation screen. By searching for genes showing a congruent signal across multiple datasets, we were able to identify a robust set of candidate loci contributing to the background-dependent effects of mutations in sd. We also show that the majority of background-dependent modifiers previously reported are caused by higher-order epistasis, not quantitative noncomplementation. These findings provide a useful foundation for more detailed investigations of genetic background dependence in this system, and this approach is likely to prove useful in exploring the genetic basis of other traits as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.