ArticleEpigenetics2014
Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia.
Article in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A systematic review and metaanalysis of observational studies on the effects of epigenetic factors on serum triglycerides.Archives of endocrinology and metabolism · 2022Pooled it
- Sex differences in cardiovascular epigenetics-a systematic review.Biology of sex differences · 2018Pooled it
- Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.Human molecular genetics · 2016Pooled it
- DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway.Clinical epigenetics · 2025Article
- Blood-based HYAL2 methylation as a potential marker for the preclinical detection of coronary heart disease and stroke.Clinical epigenetics · 2024Article
- Does epigenetic markers of HLA gene show association with coronary artery disease in Indian subjects?Molecular biology reports · 2024Article
- Methylation status ofEpigenomics · 2024Article
- Social Determinants of Health and Cerebral Small Vessel Disease: Is Epigenetics a Key Mediator?Journal of the American Heart Association · 2023Review
- Sex-specific DNA methylation: impact on human health and development.Molecular genetics and genomics : MGG · 2022Review
- Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease.Molecular biology reports · 2022Article
- Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial Hypercholesterolemia.Genes · 2022Review
- Familial Hypercholesterolemia: Do HDL Play a Role?Biomedicines · 2021Review
- Genetic basis of hypercholesterolemia in adults.NPJ genomic medicine · 2021Article
- Machine learning modelling of blood lipid biomarkers in familial hypercholesterolaemia versus polygenic/environmental dyslipidaemia.Scientific reports · 2021Article
- Differential DNA methylation in familial hypercholesterolemia.EBioMedicine · 2020Article
- Probing the epigenetic signatures in subjects with coronary artery disease.Molecular biology reports · 2020Article
- Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese population.Clinical epigenetics · 2019Article
- Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoEArteriosclerosis, thrombosis, and vascular biology · 2018Article
- Machine learning algorithm-based risk prediction model of coronary artery disease.Molecular biology reports · 2018Article
- A preliminary study of the association between theMolecular biology research communications · 2018Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Gene polymorphisms associated so far with plasma lipid concentrations explain only a fraction of their heritability, which can reach up to 60%. Recent studies suggest that epigenetic modifications (DNA methylation) could contribute to explain part of this missing heritability. We therefore assessed whether the DNA methylation of key lipoprotein metabolism genes is associated with high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride levels in patients with familial hypercholesterolemia (FH). Untreated FH patients (61 men and 37 women) were recruited for the measurement of blood DNA methylation levels at the ABCG1, LIPC, PLTP and SCARB1 gene loci using bisulfite pyrosequencing. ABCG1, LIPC and PLTP DNA methylation was significantly associated with HDL-C, LDL-C and triglyceride levels in a sex-specific manner (all P<0.05). FH subjects with previous history of coronary artery disease (CAD) had higher LIPC DNA methylation levels compared with FH subjects without CAD (P = 0.02). Sex-specific multivariable linear regression models showed that new and previously reported epipolymorphisms (ABCG1-CpGC3, LIPC-CpGA2, mean PLTP-CpGC, LPL-CpGA3, CETP-CpGA2, and CETP-CpGB2) significantly contribute to variations in plasma lipid levels (all P<0.001 in men and P<0.02 in women), independently of traditional predictors such as age, waist circumference, blood pressure, fasting plasma lipids and glucose levels. These results suggest that epigenetic perturbations of key lipoprotein metabolism genes are associated with plasma lipid levels, contribute to the interindividual variability and might partially explain the missing heritability of plasma lipid levels, at least in FH.
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