ArticleGenome biology and evolution2014
Polar bears exhibit genome-wide signatures of bioenergetic adaptation to life in the arctic environment.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Regulatory activity and evolutionary co-option of cis-regulatory elements underlying bear hibernation.Molecular biology and evolution · 2026Article
- The genomic basis of independent marine transitions in turtles: convergent episodic adaptation and demographic shifts.Molecular biology and evolution · 2026Article
- Where the microbes aren't.FEMS microbiology reviews · 2025Review
- Comparative mitogenomic analysis of subterranean and surface amphipods (Crustacea, Amphipoda) with special reference to the family Crangonyctidae.BMC genomics · 2024Article
- Insights into bear evolution from a Pleistocene polar bear genome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Long-read isoform sequencing reveals tissue-specific isoform expression between active and hibernating brown bears (Ursus arctos).G3 (Bethesda, Md.) · 2022Article
- Fatty acid profiles of feeding and fasting bears: estimating calibration coefficients, the timeframe of diet estimates, and selective mobilization during hibernation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling.Communications biology · 2022Article
- Pervasive Genomic Signatures of Local Adaptation to Altitude Across Highland Specialist Andean Hummingbird Populations.The Journal of heredity · 2021Article
- Patterns of Natural Selection on Mitochondrial Protein-Coding Genes in Lungless Salamanders: Relaxed Purifying Selection and Presence of Positively Selected Codon Sites in the Family Plethodontidae.International journal of genomics · 2021Article
- Polar bear evolution is marked by rapid changes in gene copy number in response to dietary shift.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Parallel Molecular Evolution in Pathways, Genes, and Sites in High-Elevation Hummingbirds Revealed by Comparative Transcriptomics.Genome biology and evolution · 2019Article
- Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA).Scientific reports · 2019Article
- Divergence history and hydrothermal vent adaptation of decapod crustaceans: A mitogenomic perspective.PloS one · 2019Article
- Landscape genomics: natural selection drives the evolution of mitogenome in penguins.BMC genomics · 2018Article
- Migration-Selection Balance Drives Genetic Differentiation in Genes Associated with High-Altitude Function in the Speckled Teal (Anas flavirostris) in the Andes.Genome biology and evolution · 2018Article
- De novo assembling and primary analysis of genome and transcriptome of gray whale Eschrichtius robustus.BMC evolutionary biology · 2017Article
- Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears.Scientific reports · 2017Article
- Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles.Molecular biology and evolution · 2017Article
- Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polar bears (Ursus maritimus) face extremely cold temperatures and periods of fasting, which might result in more severe energetic challenges than those experienced by their sister species, the brown bear (U. arctos). We have examined the mitochondrial and nuclear genomes of polar and brown bears to investigate whether polar bears demonstrate lineage-specific signals of molecular adaptation in genes associated with cellular respiration/energy production. We observed increased evolutionary rates in the mitochondrial cytochrome c oxidase I gene in polar but not brown bears. An amino acid substitution occurred near the interaction site with a nuclear-encoded subunit of the cytochrome c oxidase complex and was predicted to lead to a functional change, although the significance of this remains unclear. The nuclear genomes of brown and polar bears demonstrate different adaptations related to cellular respiration. Analyses of the genomes of brown bears exhibited substitutions that may alter the function of proteins that regulate glucose uptake, which could be beneficial when feeding on carbohydrate-dominated diets during hyperphagia, followed by fasting during hibernation. In polar bears, genes demonstrating signatures of functional divergence and those potentially under positive selection were enriched in functions related to production of nitric oxide (NO), which can regulate energy production in several different ways. This suggests that polar bears may be able to fine-tune intracellular levels of NO as an adaptive response to control trade-offs between energy production in the form of adenosine triphosphate versus generation of heat (thermogenesis).
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