ArticleScience (New York, N.Y.)2014
Secreting and sensing the same molecule allows cells to achieve versatile social behaviors.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed.
- Macrophage-Fibroblast Crosstalk in Kidney Injury: A Narrative Review.International journal of molecular sciences · 2026Review
- Predictability can be dynamically constructed in deterministic systems.Nature communications · 2026Article
- Pattern Formation in a Spatial Public Goods Dilemma due to Diffusive or Directed Motion.Bulletin of mathematical biology · 2026Article
- Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026Review
- Engineered Optogenetic Circuits In Yeast with Self-Sustained Outputs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Quantitative analysis of bacterial cell-cell communication at the single-cell level using microdroplet arrays.Communications biology · 2026Article
- Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast.Science advances · 2026Article
- Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Quantifying Information Exchange Between Cells in Inflammaging.Bioengineering (Basel, Switzerland) · 2026Article
- Genetically Engineered Yeast for Enhanced Biodegradation of Β-lactam Antibiotics.Applied biochemistry and biotechnology · 2025Article
- Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization.Physiology (Bethesda, Md.) · 2025Review
- Review
- Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024Article
- Dynamic altruistic cooperation within breast tumors.Molecular cancer · 2023Article
- Quorum sensing going wild.iScience · 2023Review
- Global quantitative understanding of non-equilibrium cell fate decision-making in response to pheromone.iScience · 2023Article
- Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones.BMC ecology and evolution · 2023Article
- A circuit for secretion-coupled cellular autonomy in multicellular eukaryotic cells.Molecular systems biology · 2023Article
- Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model.Entropy (Basel, Switzerland) · 2023Article
- Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast.ACS synthetic biology · 2023Article
35 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Cells that secrete and sense the same signaling molecule are ubiquitous. To uncover the functional capabilities of the core "secrete-and-sense" circuit motif shared by these cells, we engineered yeast to secrete and sense the mating pheromone. Perturbing each circuit element revealed parameters that control the degree to which the cell communicated with itself versus with its neighbors. This tunable interplay of self-communication and neighbor communication enables cells to span a diverse repertoire of cellular behaviors. These include a cell being asocial by responding only to itself and social through quorum sensing, and an isogenic population of cells splitting into social and asocial subpopulations. A mathematical model explained these behaviors. The versatility of the secrete-and-sense circuit motif may explain its recurrence across species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.