ArticleScience (New York, N.Y.)2014
Interchromosomal communication coordinates intrinsically stochastic expression between alleles.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 92 citations in OpenAlex.
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- Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
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- Activating and repressing gene expression between chromosomes during stochastic fate specification.Cell reports · 2023Article
- Altering enhancer-promoter linear distance impacts promoter competition in cis and in trans.Genetics · 2022Article
- Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies.Developmental cell · 2022Article
- Mating-driven variability in olfactory local interneuron wiring.Science advances · 2022Article
- Transcriptional repression in stochastic gene expression, patterning, and cell fate specification.Developmental biology · 2022Article
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- Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.PLoS genetics · 2021Article
- Multi-Scale Organization of theGenes · 2021Review
- Interdependent regulation of stereotyped and stochastic photoreceptor fates in the fly eye.Developmental biology · 2021Article
- The Causes and Consequences of Spatial Organization of the Genome in Regulation of Gene Expression.Frontiers in immunology · 2021Review
- Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells inG3 (Bethesda, Md.) · 2020Article
- Ordered patterning of the sensory system is susceptible to stochastic features of gene expression.eLife · 2020Article
- Unraveling cis and trans regulatory evolution during cotton domestication.Nature communications · 2019Article
- Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation.Developmental cell · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sensory systems use stochastic mechanisms to diversify neuronal subtypes. In the Drosophila eye, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) determines a random binary subtype choice in R7 photoreceptors. Here, we show that a stochastic, cell-autonomous decision to express ss is made intrinsically by each ss locus. Stochastic on or off expression of each ss allele is determined by combinatorial inputs from one enhancer and two silencers acting at long range. However, the two ss alleles also average their frequency of expression through up-regulatory and down-regulatory interallelic cross-talk. This inter- or intrachromosomal long-range regulation does not require endogenous ss chromosomal positioning or pairing. Therefore, although individual ss alleles make independent stochastic choices, interchromosomal communication coordinates expression state between alleles, ensuring that they are both expressed in the same random subset of R7s.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.