ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2014
γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- Amelioration of Acute Oxazolone-Induced Colitis via Oral Administration of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel Disease.Biomedicines · 2026Article
- IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression.Investigative ophthalmology & visual science · 2025Article
- Uncovering the mysteries of human gamma delta T cells: from origins to novel therapeutics.Frontiers in immunology · 2025Review
- Modeling Notch Activity and Lineage Decisions Using Intestinal Organoids.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?Pharmaceuticals (Basel, Switzerland) · 2021Review
- Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice.Frontiers in cell and developmental biology · 2021Article
- Intestinal Mucosal Wound Healing and Barrier Integrity in IBD-Crosstalk and Trafficking of Cellular Players.Frontiers in medicine · 2021Review
- γδ T Cells Control Gut Pathology in a Chronic Inflammatory Model of Colorectal Cancer.Cellular and molecular gastroenterology and hepatology · 2021Article
- Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets.Veterinary medicine international · 2020Article
- Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives.Microorganisms · 2018Review
- Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.Current pathobiology reports · 2018Article
- Sentinels at the frontline: the role of intraepithelial lymphocytes in inflammatory bowel disease.Current pharmacology reports · 2017Article
- New insights into the gut as the driver of critical illness and organ failure.Current opinion in critical care · 2017Review
- Article
- Chronic Inflammation and γδ T Cells.Frontiers in immunology · 2016Review
- Innate-like lymphocytes in intestinal infections.Current opinion in infectious diseases · 2015Review
- Regulatory immune cells in regulation of intestinal inflammatory response to microbiota.Mucosal immunology · 2015Review
- Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway.Nutrition research and practice · 2015Article
- γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice.Gastroenterology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Intestinal homeostasis is maintained by a hierarchy of immune defenses acting in concert to minimize contact between luminal microorganisms and the intestinal epithelial cell surface. The intestinal mucus layer, covering the gastrointestinal tract epithelial cells, contributes to mucosal homeostasis by limiting bacterial invasion. In this study, we used γδ T-cell-deficient (TCRδ(-/-)) mice to examine whether and how γδ T-cells modulate the properties of the intestinal mucus layer. Increased susceptibility of TCRδ(-/-) mice to dextran sodium sulfate (DSS)-induced colitis is associated with a reduced number of goblet cells. Alterations in the number of goblet cells and crypt lengths were observed in the small intestine and colon of TCRδ(-/-) mice compared with C57BL/6 wild-type (WT) mice. Addition of keratinocyte growth factor to small intestinal organoid cultures from TCRδ(-/-) mice showed a marked increase in crypt growth and in both goblet cell number and redistribution along the crypts. There was no apparent difference in the thickness or organization of the mucus layer between TCRδ(-/-) and WT mice, as measured in vivo. However, γδ T-cell deficiency led to reduced sialylated mucins in association with increased gene expression of gel-secreting Muc2 and membrane-bound mucins, including Muc13 and Muc17. Collectively, these data provide evidence that γδ T cells play an important role in the maintenance of mucosal homeostasis by regulating mucin expression and promoting goblet cell function in the small intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.