ArticleScientific reports2014
Among overweight middle-aged men, first-borns have lower insulin sensitivity than second-borns.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Sibling rank and sibling number in relation to cardiovascular disease and mortality risk: a nationwide cohort study.BMJ open · 2021Article
- Incidence of infants born small- and large-for-gestational-age in an Italian cohort over a 20-year period and associated risk factors.Italian journal of pediatrics · 2016Article
- Prehypertension in adolescents with cardiovascular risk: a comparison between type 1 diabetic patients and overweight subjects.BMC research notes · 2016Observational
- Damaging effects of multi-walled carbon nanotubes on pregnant mice with different pregnancy times.Scientific reports · 2014Article
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7 authors.
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Abstract
We aimed to assess whether birth order affects metabolism and body composition in overweight middle-aged men. We studied 50 men aged 45.6 ± 5.5 years, who were overweight (BMI 27.5 ± 1.7 kg/m(2)) but otherwise healthy in Auckland, New Zealand. These included 26 first-borns and 24 second-borns. Insulin sensitivity was assessed by the Matsuda method from an oral glucose tolerance test. Other assessments included DXA-derived body composition, lipid profiles, 24-hour ambulatory blood pressure, and carotid intima-media thickness. First-born men were 6.9 kg heavier (p = 0.013) and had greater BMI (29.1 vs 27.5 kg/m(2); p = 0.004) than second-borns. Insulin sensitivity in first-born men was 33% lower than in second-borns (4.38 vs 6.51; p = 0.014), despite adjustment for fat mass. There were no significant differences in ambulatory blood pressure, lipid profile or carotid intima-media thickness between first- and second-borns. Thus, first-born adults may be at a greater risk of metabolic and cardiovascular diseases.
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