ArticlePloS one2014
Comparative genomic hybridization identifies virulence differences in Streptococcus suis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genomic epidemiology inHeliyon · 2024Review
- Evaluation of pathotype marker genes in Streptococcus suis isolated from human and clinically healthy swine in Thailand.BMC microbiology · 2023Article
- Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.PloS one · 2023Article
- Genomic and pathogenic investigations ofEmerging microbes & infections · 2021Article
- Genomic Characterization ofFrontiers in microbiology · 2021Article
- Tools for Molecular Epidemiology ofPathogens (Basel, Switzerland) · 2020Review
- Genomic Epidemiology ofPathogens (Basel, Switzerland) · 2019Article
- Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.Veterinary research · 2018Article
- Article
- Virulence Studies of Different Sequence Types and Geographical Origins of Streptococcus suis Serotype 2 in a Mouse Model of Infection.Pathogens (Basel, Switzerland) · 2016Article
- Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.Nature communications · 2015Article
- Population analysis of Streptococcus suis isolates from slaughtered swine by use of minimum core genome sequence typing.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis is an important zoonotic pathogen. However, identification of virulent S. suis strains is complicated because of the high diversity of the species. Here we evaluated the genetic difference among S. suis strains using comparative genomic hybridization (CGH) and virulence variation in vivo and in vitro. We showed that different clades differed in their ability to activate TLR2/6 in vitro and their capacity to induce cytokine production in vivo as well as their resistance to phagocytosis and survival in vivo. Our data showed the S. suis strains tested can be classified into three groups having differing levels of virulence: epidemic and highly virulent strains were clustered into clade Ia (epidemic and highly virulent group, E/HV group), virulent strains were clustered into clade Ib (virulent group, V group), and intermediately or weakly virulent strains were clustered into other clades (intermediately or weakly virulent group, I/WV group). Our study provided further insight into the genomic and virulence variation of S. suis.
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