ArticleObesity facts2014
Adipogenic effects of a combination of the endocrine-disrupting compounds bisphenol A, diethylhexylphthalate, and tributyltin.
Article in Obesity facts, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Prenatal Exposure to Bisphenol A and/or Diethylhexyl Phthalate Impacts Brain Monoamine Levels in Rat Offspring.Journal of xenobiotics · 2024Article
- Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring.Frontiers in endocrinology · 2024Article
- Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes.Archives of toxicology · 2023Article
- Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions.Pharmaceutics · 2023Review
- Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A.Scientific reports · 2023Article
- Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants-A Review.International journal of molecular sciences · 2023Review
- Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner.Frontiers in toxicology · 2023Article
- Article
- Identifying windows of susceptibility to endocrine disrupting chemicals in relation to gestational weight gain among pregnant women attending a fertility clinic.Environmental research · 2021Article
- Automated lipid droplet quantification system for phenotypic analysis of adipocytes using CellProfiler.Toxicology mechanisms and methods · 2020Article
- The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk.Endocrine connections · 2020Article
- Phthalate Exposure and Long-Term Epigenomic Consequences: A Review.Frontiers in genetics · 2020Review
- Bisphenol a: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma.Environmental research · 2019Review
- Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps.Trends in endocrinology and metabolism: TEM · 2018Review
- Pregnancy urinary bisphenol-A concentrations and glucose levels across BMI categories.Environment international · 2018Article
- DEHP deregulates adipokine levels and impairs fatty acid storage in human SGBS-adipocytes.Scientific reports · 2018Article
- Environmental Pollutants and Metabolic Disorders: The Multi-Exposure Scenario of Life.Frontiers in endocrinology · 2018Review
- Urinary phthalate metabolite concentrations and maternal weight during early pregnancy.International journal of hygiene and environmental health · 2017Article
- Endocrine Disrupting Chemicals, Transgenerational Epigenetics and Metabolic Diseases.EC endocrinology and metabolic research · 2017Article
- Bisphenol A and Metabolic Diseases: Challenges for Occupational Medicine.International journal of environmental research and public health · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe food contaminants bisphenol A (BPA), diethylhexylphthalate (DEHP), and tributyltin (TBT) are potent endocrine-disrupting compounds (EDC) known to interfere with adipogenesis. EDC usually act in mixtures and not as single compounds. The aim of this study was to investigate the effects of a simultaneous exposure of BPA, DEHP, and TBT on mesenchymal stem cell differentiation into adipocytes.
methodsMultipotent murine mesenchymal stem cells (C3H10T1/2) were exposed to EDC mixtures in high concentrations, i.e. MIX-high (10 µmol/l BPA, 100 µmol/l DEHP, 100 nmol/l TBT), and in environmentally relevant concentrations, i.e. MIX-low (10 nmol/l BPA, 100 nmol/l DEHP, 1 nmol/l TBT). The exposure was performed either for the entire culture time (0-12 days) or at distinct stages of adipogenic differentiation. At day 12 of cell culture, the amount of adipocytes, triglyceride content (TG), and adipogenic marker gene expression were analyzed.
resultsMIX-high increased the development of adipocytes and the expression of adipogenic marker genes independently of the exposure window. The total TG amount was not increased. The low-concentrated EDC mixture had no obvious impact on adipogenesis.
conclusionIn EDC mixtures, the adipogenic effect of TBT and DEHP predominates single effects of BPA. Mixture effects of EDC are not deducible from single compound experiments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.