Evidence map›Paper›PMID 24503412›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2014

Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

Inok Surh, Deepa B Rao, Mark F Cesta, Charles D Hébert, Jill F Mann, Helen Cunny, Grace E Kissling, David Malarkey, Rajendra S Chhabra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Inok SurhNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: surhi@niehs.nih.gov.
Deepa B RaoNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27709, USA.
Mark F CestaNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Charles D HébertSouthern Research Institute, Birmingham, AL 35255, USA.
Jill F MannSouthern Research Institute, Birmingham, AL 35255, USA.
Helen CunnyNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Grace E KisslingNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
David MalarkeyNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Rajendra S ChhabraNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Triangle · USSouthern Research Institute · USIntegrated Laboratory Systems, Inc. · USNational Institute of Environmental Health Sciences · US

Funding

NTP Database Summarization And EvaluationZIAES045004 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KISSLING, GRACE E · 2009 to 2017
$1.2M
Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

Trimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2 years. There were no differences in the body weights and survival in the treated animals compared to controls. Nonneoplastic skin lesions at the site of application included epidermal hyperplasia and hyperkeratosis in both rats and mice. There were no incidences of tumors at the site of application in rats and mice. Rare malignant liver neoplasms were observed in female mice that included hepatoblastoma in the 0.3 and 3.0mg/kg groups, and hepatocholangiocarcinoma in the 1.0 and 3.0mg/kg groups. The incidences of uterine stromal polyp and stromal polyp or stromal sarcoma (combined) in female mice occurred with positive trends and the incidences were significantly increased in the 3.0mg/kg group. A marginal increase in the incidences of malignant mesothelioma in male rats may have been related to TMPTA treatment. In conclusion, our studies show that TMPTA is a dermal irritant in both rats and mice of either sex. Increased incidences of tumor formation were observed in female mice and male rats.

Indexed as

Sex FactorsAcrylatesAnimalsCarcinogensFemaleMaleMiceRatsRats, Inbred F344Species SpecificityAcrylatesCarcinogenstrimethylolpropane triacrylateCarcinogenicityLiverSkinTrimethylolpropane triacrylateUterine

Identifiers

PMID24503412
PMCPMC3995139
OpenAlexW2010941074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.