Intersection of complex genetic traits affecting maternal metabolism, fetal metabolism, and neural tube defect risk: looking for needles in multiple haystacks.

Mary R Loeken

Abstract read

In one paragraph

Article in Molecular genetics and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed, 2 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2023
Pooled it
Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes.American journal of epidemiology · 2017
Pooled it
Digenic variants of planar cell polarity genes in human neural tube defect patients.Molecular genetics and metabolism · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Mary R LoekenSection on Islet and Regenerative Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA. Electronic address: mary.loeken@joslin.harvard.edu.

Funding

SEARCH FOR THE MOLECULAR CAUSES OF DIABETIC EMBRYOPATHYR01DK052865 · NIDDK · JOSLIN DIABETES CENTER · PI LOEKEN, MARY R · 1998 to 2013

$4.4M

MOLECULAR REGULATION: EMBYROGENESIS BY METABOLIC STRESSR01DK058300 · NIDDK · JOSLIN DIABETES CENTER · PI LOEKEN, MARY R · 2000 to 2014

$4.3M

NIDDK NIH HHS R01 DK052865NIDDK NIH HHS R01 DK058300NIDDK NIH HHS R01DK52865NIDDK NIH HHS R01DK58300

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Predisposition to DiseaseQuantitative Trait, HeritableFemaleFetusGenome-Wide Association StudyGlucose Transporter Type 2HumansNeural Tube DefectsPolymorphism, Single NucleotideRisk FactorsGlucose Transporter Type 2DiabetesFuel metabolismGlucose transportInsulin resistanceNeural tube defect

Identifiers

PMID24503137

DOI10.1016/j.ymgme.2014.01.010

PMCPMC3982189

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.