Evidence map›Paper›PMID 24503062›Full record

ArticleVirology2014

Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen?

Andrew B Allison, M Kevin Keel, Jamie E Philips, Andrew N Cartoceti, Brandon A Munk, Nicole M Nemeth, Trista I Welsh, Jesse M Thomas, James M Crum, Anne B Lichtenwalner and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. First Report of Marek's Disease Virus in Commercial Turkeys in Slovenia.Animals : an open access journal from MDPI · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Andrew B AllisonBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA; Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. Electronic address: aba75@cornell.edu.
M Kevin KeelSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Jamie E PhilipsSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Andrew N CartocetiSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Brandon A MunkSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Nicole M NemethSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Trista I WelshSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Jesse M ThomasSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
James M CrumWest Virginia Division of Natural Resources, Elkins, WV 26241, USA.
Anne B LichtenwalnerDepartment of Animal and Veterinary Sciences, University of Maine Animal Health Laboratory, University of Maine, Orono, ME 04469, USA.
Aly M FadlyUnited States Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA.
Guillermo ZavalaPoultry Diagnostic Research Center, Department of Population Health, University of Georgia, Athens, GA 30602, USA.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Biological Sciences and Sydney Medical School, University of Sydney, NSW 2006, Australia.
Justin D BrownSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
University of Georgia · USAgricultural Research Service · USThe University of Sydney · AUUniversity of Maine · USWest Virginia Division of Natural Resources · US

Funding

Host cell receptor variation and control of viral cross-species transmissionF32AI100545 · NIAID · CORNELL UNIVERSITY · PI ALLISON, ANDREW BROWNELL · 2013 to 2015
$165k
NIAID NIH HHS F32 AI100545NIAID NIH HHS F32AI100545
6 · The paper itself

Abstract

Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88% nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown.

Indexed as

AlpharetrovirusAnimalsCarcinogenesisCommunicable Diseases, EmergingEvolution, MolecularMolecular Sequence DataNeglected DiseasesPhylogenyPoultry DiseasesRetroviridae InfectionsTumor Virus InfectionsTurkeysUnited StatesAlpharetrovirusAvian tumor virusesExogenous retrovirusLymphoproliferative disease virus (LPDV)OncogenesisOrder Galliformes

Identifiers

PMID24503062
PMCPMC3925403
OpenAlexW2084137317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.