Evidence map›Paper›PMID 24502751›Full record

Trial reportBMC nephrology2014

Ecological momentary assessment of fatigue, sleepiness, and exhaustion in ESKD.

Khaled Abdel-Kader, Manisha Jhamb, Lee Anne Mandich, Jonathan Yabes, Robert M Keene, Scott Beach, Daniel J Buysse, Mark L Unruh

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Impact of worst pain severity and morning fatigue profiles on oncology outpatients' symptom burden and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  15. Review
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  18. Patient-reported outcomes in maintenance hemodialysis: a cross-sectional, multicenter study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khaled Abdel-KaderDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, 1161 21st Avenue South, MCN S-3223, Nashville, TN 37232-2372, USA. khaled.abdel-kader@vanderbilt.edu.
Manisha Jhamb
Lee Anne Mandich
Jonathan Yabes
Robert M Keene
Scott Beach
Daniel J Buysse
Mark L Unruh

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Impact of Nocturnal Hemodialysis on Sleep Apnea, Sleep Quality & Daytime SymptomsR01DK077785 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI UNRUH, MARK LYNN · 2007 to 2011
$1.3M
Developing, Validating, and Implementing a CKD Predictive Model (DELVECKD)K23DK090304 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABDEL-KADER, KHALED A · 2011 to 2015
$861k
Sleep and Daytime Functioning in Chronic Kidney DiseaseK23DK066006 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI UNRUH, MARK LYNN · 2004 to 2008
$710k
NCATS NIH HHS UL1 TR000005NIDDK NIH HHS K23 DK066006NIDDK NIH HHS K23 DK090304NIDDK NIH HHS K23DK090304NIDDK NIH HHS L30 DK093114NIDDK NIH HHS R01 DK077785NIDDK NIH HHS R01DK077785
6 · The paper itself

Abstract

backgroundMany patients on maintenance dialysis experience significant sleepiness and fatigue. However, the influence of the hemodialysis (HD) day and circadian rhythms on patients' symptoms have not been well characterized. We sought to use ecological momentary assessment to evaluate day-to-day and diurnal variability of fatigue, sleepiness, exhaustion and related symptoms in thrice-weekly maintenance HD patients.

methodsSubjects used a modified cellular phone to access an interactive voice response system that administered the Daytime Insomnia Symptom Scale (DISS). The DISS assessed subjective vitality, mood, and alertness through 19 questions using 7- point Likert scales. Subjects completed the DISS 4 times daily for 7 consecutive days. Factor analysis was conducted and a mean composite score of fatigue-sleepiness-exhaustion was created. Linear mixed regression models (LMM) were used to examine the association of time of day, dialysis day and fatigue, sleepiness, and exhaustion composite scores.

resultsThe 55 participants completed 1,252 of 1,540 (81%) possible assessments over the 7 day period. Multiple symptoms related to mood (e.g., feeling sad, feeling tense), cognition (e.g., difficulty concentrating), and fatigue (e.g., exhaustion, feeling sleepy) demonstrated significant daily and diurnal variation, with higher overall symptom scores noted on hemodialysis days and later in the day. In factor analysis, 4 factors explained the majority of the observed variance for DISS symptoms. Fatigue, sleepiness, and exhaustion loaded onto the same factor and were highly intercorrelated. In LMM, mean composite fatigue-sleepiness-exhaustion scores were associated with dialysis day (coefficient and 95% confidence interval [CI] 0.21 [0.02 - 0.39]) and time of day (coefficient and 95% CI 0.33 [0.25 - 0.41]. Observed associations were minimally affected by adjustment for demographics and common confounders.

conclusionsMaintenance HD patients experience fatigue-sleepiness-exhaustion symptoms that demonstrate significant daily and diurnal variation. The variability in symptoms may contribute to poor symptom awareness by providers and greater misclassification bias of fatigue related symptoms in clinical studies.

Indexed as

Disorders of Excessive SomnolenceFatigueFemaleHealth Care CostsHumansKidney Failure, ChronicMaleMiddle AgedRenal DialysisTreatment OutcomeUnited States

Identifiers

PMID24502751
PMCPMC3927224

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.