ArticleJournal of ovarian research2014
Association between circulating adiponectin levels and polycystic ovarian syndrome.
Article in Journal of ovarian research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04867252 (Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome
Who cites it
21 citing papers in PubMed.
- Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial.Journal of ovarian research · 2019Trial
- Adipokine Profile Signature in Adolescent Girls with Menstrual Disorders and Hyperandrogenism Differs from That of Regularly Menstruating Girls.Journal of clinical medicine · 2025Article
- Improved ovarian adiponectin system expression in polycystic ovary syndrome treated with exenatide.Clinical and experimental reproductive medicine · 2025Article
- Adipokines as biochemical marker of polycystic ovary syndrome in adolescents - review.Frontiers in endocrinology · 2025Review
- The role of immunity in insulin resistance in patients with polycystic ovary syndrome.Frontiers in endocrinology · 2024Review
- Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs.Frontiers in endocrinology · 2023Review
- Review
- Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin.Metabolism open · 2022Article
- Gallic acid reverses ovarian disturbances in mice with letrozole-induced PCOS via modulating Adipo R1 expression.Toxicology reports · 2022Article
- The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator.International journal of tryptophan research : IJTR · 2022Review
- Progress of Adipokines in the Female Reproductive System: A Focus on Polycystic Ovary Syndrome.Frontiers in endocrinology · 2022Review
- Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10.Stem cell research & therapy · 2021Article
- Inflammation and reproductive function in women with polycystic ovary syndrome†.Biology of reproduction · 2021Review
- PCOSKBScientific reports · 2020Article
- A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome.Journal of functional morphology and kinesiology · 2020Review
- Liraglutide modulates adipokine expression during adipogenesis, ameliorating obesity, and polycystic ovary syndrome in mice.Endocrine · 2019Article
- Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of theKorean journal of family medicine · 2018Article
- New Therapeutic Approaches in Obesity and Metabolic Syndrome Associated with Polycystic Ovary Syndrome.Cureus · 2017Review
- Evidence for decreased expression of APPL1 associated with reduced insulin and adiponectin receptors expression in PCOS patients.Journal of endocrinological investigation · 2016Article
- A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the role of adiponectin in younger and lean patients are limited. Therefore, the aim of the present study was to examine the association of adiponectin levels in young and lean women with PCOS.
methodsA case-control study was conducted at the Dow University of Health Sciences, Karachi, Pakistan. Cases were 75 patients of PCOS with Body Mass Index (BMI) &23 aged 16-35 years and 75 healthy age and BMI matched controls were selected from family and friends of the cases. Demographic details, family history and past medical history were obtained through interview by a physician. Anthropometric measurements included weight and height of the participants. Fasting glucose, total cholesterol, high-density lipoprotein (HDL), insulin, adiponectin, and androgen levels were determined. IR was calculated using homeostasis model assessment for insulin resistance (HOMA-IR). Logistic regression models were used to assess the association between adiponectin and PCOS after adjusting for co-variates.
resultsOn multivariable analysis, PCOS cases were 3.2 times more likely to have low adiponectin level (OR = 3.2, 95% CI 1.49-6.90, p-value 0.003) compared to the controls after adjustment for age, BMI, family history, marital status, total cholesterol, HDL level and IR. Females with a family history of PCOS were significantly more likely to have lower adiponectin (OR = 3.32, 95% CI 1.27-8.67, p-value 0.014) compared to those who did not have a family history of PCOS. The associations of IR and family history with low adiponectin level also remained statistically significant after adjustments for covariates.
conclusionSerum adiponectin levels are independently associated with PCOS and are only partly explained by IR. Adiponectin level may serve as a potential independent biomarker for diagnosis of PCOS in young and lean women with fewer symptoms, or women with a family history of PCOS.
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