Molecular profiles of papillary thyroid tumors have been changing in the last decades: how could we explain it?

Rossella Elisei

Erratum issuedAbstract readEditorialComment

In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review.Oncotarget · 2017
Pooled it
Epidemiology of Thyroid Cancer in Tuscany (Central Italy) 2013-2017: Not Just Overdiagnosis.Cancers · 2025
Article
Heavy Metals in the Environment and Thyroid Cancer.Cancers · 2021
Review
Increased Thyroid Cancer Incidence in Volcanic Areas: A Role of Increased Heavy Metals in the Environment?International journal of molecular sciences · 2020
Review
Current Advances in Thyroid Cancer Management. Are We Ready for the Epidemic Rise of Diagnoses?International journal of molecular sciences · 2017
Review
Review of Factors Related to the Thyroid Cancer Epidemic.International journal of endocrinology · 2017
Review
Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer.Pathology oncology research : POR · 2016
Article
[Total thyroidectomy with lymph node dissection of the central compartment for node-positive, capsular invasive papillary thyroid cancer: video contribution].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2014
Article

4 · The record

Corrections and comments

Comment on
The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations.2014
Erratum issued

5 · Who and what money

Authors and funding

1 author.

Rossella EliseiUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAdenomaCarcinoma, PapillaryFemaleHumansMaleProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Thyroid NeoplasmsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)

Identifiers

PMID24502514

DOI10.1210/jc.2014-1130

PMCPMC4019813

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.