ArticleNeuroImage. Clinical2014
Widespread brain dysconnectivity associated with psychotic-like experiences in the general population.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Schizotypal Traits are Linked to Dopamine-Induced Striato-Cortical Decoupling: A Randomized Double-Blind Placebo-Controlled Study.Schizophrenia bulletin · 2019Trial
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- The Salience of Psychotic Experiences: Neural Correlates in the General Population.Schizophrenia bulletin · 2026Article
- Longitudinal hippocampal subfield development associated with psychotic experiences in young people.Translational psychiatry · 2024Article
- Resting-State Functional Connectivity Explained Psychotic-like Experiences in the General Population and Partially Generalized to Patients and Relatives.Biological psychiatry global open science · 2023Article
- Longitudinal Gray Matter Development Associated With Psychotic Experiences in Young People.Biological psychiatry global open science · 2023Article
- White matter, cognition and psychotic-like experiences in UK Biobank.Psychological medicine · 2023Article
- Differentiating kinds of systemic stressors with relation to psychotic-like experiences in late childhood and early adolescence: the stimulation, discrepancy, and deprivation model of psychosis.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Altered temporal, but intact spatial, features of transient network dynamics in psychosis.Molecular psychiatry · 2021Article
- Whole-Brain Functional Network Connectivity Abnormalities in Affective and Non-Affective Early Phase Psychosis.Frontiers in neuroscience · 2021Article
- Multiple Network Dysconnectivity in Adolescents with Psychotic Experiences: A Longitudinal Population-Based Study.Schizophrenia bulletin · 2020Article
- Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank.Translational psychiatry · 2020Article
- Functional Connectivity of the Striatum in Schizophrenia and Psychotic Bipolar Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.Biological psychiatry · 2019Article
- MRI Indices of Cortical Development in Young People With Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms.Schizophrenia bulletin · 2019Article
- Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences.Translational psychiatry · 2018Article
- Frequency specific resting state functional abnormalities in psychosis.Human brain mapping · 2018Article
- Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders.Schizophrenia research · 2018Article
- Psychotic-spectrum symptoms, cumulative adversity exposure and substance use among high-risk girls.Early intervention in psychiatry · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It is becoming increasingly clear that psychosis occurs along a continuum. At the high end are formal psychotic disorders such as schizophrenia, and at the low-end are individuals who experience occasional psychotic symptoms, but are otherwise healthy (non-clinical psychosis, NCP). Schizophrenia has been shown to be marked by altered patterns of connectivity between brain regions, but it is not known if such dysconnectivity exists in NCP. In the current study we used functional magnetic resonance imaging (fMRI) to compare resting-state functional connectivity in NCP individuals (n = 25) and healthy controls (n = 27) for four brain networks of interest (fronto-parietal, cingulo-opercular, default mode, and cerebellar networks). NCP individuals showed reduced connectivity compared to controls between regions of the default mode network and frontal regions, and between regions in all of the networks and the thalamus. NCP individuals showed greater connectivity compared to controls within regions of frontal control networks. Further, positive symptom scores in NCP individuals were positively correlated with connectivity between the cingulo-opercular network and the visual cortex, and were negatively correlated with connectivity between the cerebellar network and the posterior parietal cortex and dorsal premotor cortex. Connectivity was not correlated with positive symptom scores in controls. Taken together, these findings demonstrate that a spectrum of abnormal connectivity underlies the psychosis continuum, and that individuals with sub-clinical psychotic experiences represent a key population for understanding pathogenic processes.
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