Evidence map›Paper›PMID 24501590›Full record

ArticleAdvanced functional materials2010

Polymer scaffolds for small-diameter vascular tissue engineering.

Haiyun Ma, Jiang Hu, Peter X Ma

Abstract read
In one paragraph

Article in Advanced functional materials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Biological aspects in controlling angiogenesis: current progress.Cellular and molecular life sciences : CMLS · 2022
    Review
  5. Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives.Journal of dental research, dental clinics, dental prospects · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Building Scaffolds for Tubular Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Biomaterials and stem cells for tissue engineering.Expert opinion on biological therapy · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Haiyun MaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109-1078.
Jiang HuDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109-1078.
Peter X MaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109-1078 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109-1078 ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI, 48109-1078.

Funding

Periodontal Engineering Using Biomimetic Nano ScaffoldsR01DE015384 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2011
$2.9M
Orchestrating Bone Regeneration on Multiple ScalesR01DE017689 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2007 to 2010
$1.4M
NIDCR NIH HHS R01 DE015384NIDCR NIH HHS R01 DE017689
6 · The paper itself

Abstract

To better engineer small-diameter blood vessels, a few types of novel scaffolds were fabricated from biodegradable poly(L-lactic acid) (PLLA) by means of thermally induced phase separation (TIPS) techniques. By utilizing the differences in thermal conductivities of the mold materials, the scaffolds with oriented gradient microtubular structures in axial or radial direction were created using benzene as the solvent. The porosity, tubular size, and the orientation direction of the microtubules can be controlled by polymer concentration, TIPS temperature, and materials of different thermal conductivities. The gradient microtubular structure was intended to facilitate cell seeding and mass transfer for cell growth and function. We also developed nanofibrous scaffolds with oriented and interconnected micro-tubular pore network by a one-step TIPS method using benzene/tetrahydrofuran mixture as the solvent without using porogen materials. The structural features of such scaffolds can be conveniently adjusted by varying the solvent ratio, phase separation temperature and polymer concentration to mimic the nanofibrous feature of extracellular matrix. These scaffolds were fabricated for the tissue engineering of small-diameter blood vessels by utilizing their advantageous structural features to facilitate blood vessel regeneration.

Indexed as

blood vessel scaffoldnanofiberorientationPLLAthermally induced phase separation

Identifiers

PMID24501590
PMCPMC3911792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.