ArticleAncient science of life2013
Analgesic and anti-inflammatory activity of root bark of Grewia asiatica Linn. in rodents.
Article in Ancient science of life, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Chemical Composition and Health-Promoting Effects of theNutrients · 2021Pooled it
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- Review
- Spasmolytic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antinociceptive Effect of Spirocyclopiperazinium Salt Compound DXL-A-24 and the Underlying Mechanism.Neurochemical research · 2019Article
- The anti-inflammatory and analgesic properties of prosopis chilenses in rats.International journal of health sciences · 2015Article
- Antihyperglycemic Potential of Grewia asiatica Fruit Extract against Streptozotocin-Induced Hyperglycemia in Rats: Anti-Inflammatory and Antioxidant Mechanisms.Oxidative medicine and cellular longevity · 2015Article
- Analgesic and Antioxidant Activities of Stem Bark Extract and Fractions of Petersianthus macrocarpus.Pharmacognosy researchArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrewia asiatica Linn. (Family: Tiliaceae), called Phalsa in Hindi is an Indian medicinal plant used for a variety of therapeutic and nutritional uses. The root bark of the plant is traditionally used in rheumatism (painful chronic inflammatory condition).
aimsThe present study demonstrates the analgesic and anti-inflammatory activity of root bark of G. asiatica in rodents. SETTINGS AND
designThe methanolic extract of Grewia asiatica (MEGA) and aqueous extract of Grewia asiatica (AEGA) of the bark were prepared and subjected to phytochemical tests and pharmacological screening for analgesic and anti-inflammatory effect in rodents. MATERIALS AND
methodsAnalgesic effect was studied using acetic acid-induced writhing in mice and hot plate analgesia in rats while anti-inflammatory activity was investigated using carrageenan-induced paw oedema in rats. The MEGA or AEGA was administered orally in doses of 200 and 400 mg/kg/day of body weight. STATISTICAL ANALYSIS: Data were analysed by one-way analysis of variance followed by Dunnett's test.
resultsThe extracts showed a significant inhibition of writhing response and increase in hot plate reaction time and also caused a decrease in paw oedema. The effects were comparable with the standard drugs used.
conclusionsThe present study indicates that root bark of G. asiatica exhibits peripheral and central analgesic effect and anti-inflammatory activity, which may be attributed to the various phytochemicals present in root bark of G. asiatica.
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