ArticleMolecular biology of the cell2014
BAF-1 mobility is regulated by environmental stresses.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Proximity labeling at H3K9me3 reveals VRK-1 regulate global chromatin distribution inbioRxiv : the preprint server for biology · 2026Article
- Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures.Cell cycle (Georgetown, Tex.) · 2021Review
- The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction.International journal of molecular sciences · 2020Article
- Diverse cellular functions of barrier-to-autointegration factor and its roles in disease.Journal of cell science · 2020Review
- Article
- Survival ofDevelopment (Cambridge, England) · 2020Article
- RareFrontiers in cell and developmental biology · 2019Article
- Article
- The nuclear lamina in health and disease.Nucleus (Austin, Tex.) · 2016Review
- Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria.Current opinion in cell biology · 2015Review
- Networking in the nucleus: a spotlight on LEM-domain proteins.Current opinion in cell biology · 2015Review
- The molecular basis of emerin-emerin and emerin-BAF interactions.Journal of cell science · 2014Article
- Cellular mechanosensing: getting to the nucleus of it all.Progress in biophysics and molecular biology · 2014Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Barrier to autointegration factor (BAF) is an essential component of the nuclear lamina that binds lamins, LEM-domain proteins, histones, and DNA. Under normal conditions, BAF protein is highly mobile when assayed by fluorescence recovery after photobleaching and fluorescence loss in photobleaching. We report that Caenorhabditis elegans BAF-1 mobility is regulated by caloric restriction, food deprivation, and heat shock. This was not a general response of chromatin-associated proteins, as food deprivation did not affect the mobility of heterochromatin protein HPL-1 or HPL-2. Heat shock also increased the level of BAF-1 Ser-4 phosphorylation. By using missense mutations that affect BAF-1 binding to different partners we find that, overall, the ability of BAF-1 mutants to be immobilized by heat shock in intestinal cells correlated with normal or increased affinity for emerin in vitro. These results show BAF-1 localization and mobility at the nuclear lamina are regulated by stress and unexpectedly reveal BAF-1 immobilization as a specific response to caloric restriction in C. elegans intestinal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.