ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 2 of them syntheses that pooled it.
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Who cites it
159 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of Anodal Cerebellar Transcranial Direct Current Stimulation on Movements in Patients with Cerebellar Ataxias: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Probing cerebellar involvement in cognition through a meta-analysis of TMS evidence.Scientific reports · 2021Pooled it
- Article
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1.Current biology : CB · 2026Article
- Classical conditioning of Purkinje cell responsesBiochemistry and biophysics reports · 2026Article
- Comparison of Signals from Cerebellar Purkinje Cells and Deep Nuclei during Temporal Prediction in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Plasma membrane calcium ATPases and cerebellar pathology: what's the role in the ataxia?Biology direct · 2025Review
- Glutamatergic Neurons in the Cerebellar Lateral Nucleus Contribute to Motor Deficits Induced by Chronic Sleep Disturbance.Brain sciences · 2025Article
- Neuroscience of Behavior.NeuroSci · 2025Review
- Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Processing reliant on granule cells is essential for motor learning but dispensable for social preference and numerous other cerebellar-dependent behaviors.Nature communications · 2025Article
- Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.Human molecular genetics · 2024Article
- Purkinje cell ablation and Purkinje cell-specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses.The Journal of physiology · 2024Article
99 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.