Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Hippocampal binding of novel information with dominant memory traces can support both memory stability and change.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Trial
- Trial
- To learn or to gain: neural signatures of exploration in human decision-making.Brain structure & function · 2022Article
- Reinstatement of item-specific contextual details during retrieval supports recombination-related false memories.NeuroImage · 2021Article
- Hippocampus Guides Adaptive Learning during Dynamic Social Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Distinguishing the precision of spatial recollection from its success: Evidence from healthy aging and unilateral mesial temporal lobe resection.Neuropsychologia · 2018Article
- False memories, false preferences: Flexible retrieval mechanisms supporting successful inference bias novel decisions.Journal of experimental psychology. General · 2018Article
- Flexible retrieval mechanisms supporting successful inference produce false memories in younger but not older adults.Psychology and aging · 2018Article
- Distinct Hippocampal versus Frontoparietal Network Contributions to Retrieval and Memory-guided Exploration.Journal of cognitive neuroscience · 2017Article
- A Closer Look at the Hippocampus and Memory.Trends in cognitive sciences · 2017Review
- Temporal Proximity Promotes Integration of Overlapping Events.Journal of cognitive neuroscience · 2017Article
- Flexible retrieval: When true inferences produce false memories.Journal of experimental psychology. Learning, memory, and cognition · 2017Article
- Crime Scene Familiarity: Does it Influence Mock Jurors' Decisions?Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2017Article
- Repetition suppression in the medial temporal lobe and midbrain is altered by event overlap.Hippocampus · 2016Article
- Binding among select episodic elements is altered via active short-term retrieval.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Metamemory ratings predict long-term changes in reactivated episodic memories.Frontiers in behavioral neuroscience · 2015Article
- Active retrieval facilitates across-episode binding by modulating the content of memory.Neuropsychologia · 2014Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Memory stability and change are considered opposite outcomes. We tested the counterintuitive notion that both depend on one process: hippocampal binding of memory features to associatively novel information, or associative novelty binding (ANB). Building on the idea that dominant memory features, or "traces," are most susceptible to modification, we hypothesized that ANB would selectively involve dominant traces. Therefore, memory stability versus change should depend on whether the currently dominant trace is old versus updated; in either case, novel information will be bound with it, causing either maintenance (when old) or change (when updated). People in our experiment studied objects at locations within scenes (contexts). During reactivation in a new context, subjects moved studied objects to new locations either via active location recall or by passively dragging objects to predetermined locations. After active reactivation, the new object location became dominant in memory, whereas after passive reactivation, the old object location maintained dominance. In both cases, hippocampal ANB bound the currently dominant object-location memory with a context with which it was not paired previously (i.e., associatively novel). Stability occurred in the passive condition when ANB united the dominant original location trace with an associatively novel newer context. Change occurred in the active condition when ANB united the dominant updated object location with an associatively novel and older context. Hippocampal ANB of the currently dominant trace with associatively novel contextual information thus provides a single mechanism to support memory stability and change, with shifts in trace dominance during reactivation dictating the outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.