Evidence map›Paper›PMID 24501262›Full record

ArticleJournal of neurophysiology2014

Sodium-potassium ATPase emerges as a player in hippocampal phenotypes of Angelman syndrome mice.

Jada J Hallengren, Ryan J Vaden

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jada J HallengrenDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama jjh85@uab.edu.
Ryan J VadenDepartment of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · US

Funding

Newborn Neurons in the Adult Hippocampal NetworkR01NS064025 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2009 to 2023
$5.6M
The role of Usp14 in regulating neuronal functionR01NS047533 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, SCOTT MICHAEL · 2004 to 2014
$3.1M
Newborn Neurons in the Adult Hippocampal NetworkR56NS064025 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2014 to 2014
$460k
Enhancement of Proteasome Activity for the Treatment of Neurological DisordersR21NS074456 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, SCOTT MICHAEL · 2011 to 2012
$403k
NINDS NIH HHS NS-047533NINDS NIH HHS NS-064025NINDS NIH HHS NS-074456
6 · The paper itself

Abstract

Angelman syndrome is a neurodevelopmental disorder characterized by intellectual disabilities, ataxia, and unusually happy affect. The hippocampal pyramidal cells of Angelman syndrome model mice have altered intrinsic membrane properties, which Kaphzan et al. (Cell Rep 4: 405-412, 2013) demonstrate can be corrected by genetic reduction of the α1-subunit of the sodium-potassium ATPase. Intriguingly, this manipulation also restores hippocampal long-term potentiation and learning. In this Neuro Forum, we discuss translational implications of this work and remaining questions left in its wake.

Indexed as

Angelman SyndromeAnimalsFemaleHippocampusMaleSodium-Potassium-Exchanging ATPaseSodium-Potassium-Exchanging ATPaseAngelman syndromeintrinsic excitabilitylong-term potentiationsodium-potassium ATPase

Identifiers

PMID24501262
PMCPMC4064391
OpenAlexW2097221612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.